How do keratinocytes differentiate?
How do keratinocytes differentiate? A calcium gradient within the epidermis promotes the sequential differentiation of keratinocytes as they traverse the different layers of the epidermis to form the permeability barrier of the stratum corneum. Calcium promotes differentiation by both outside–in and inside–out signaling. What is terminal differentiation of keratinocytes? Keratinocyte differentiation is the process of cellular maturation from a mitotic state to a terminally differentiated state during which skin builds up a tough yet soft skin barrier to protect the body. How does a keratinocyte work? Keratinocyte stem cells reside in the basal layer of the epidermis, which is the...