What is the function of ICAM-1?
What is the function of ICAM-1?
ICAM-1 plays a role in inflammatory processes and in the T-cell mediated host defense system. It functions as a costimulatory molecule on antigen-presenting cells to activate MHC class II restricted T-cells, and on other cell types in association with MHC class I to activate cytotoxic T-cells.
What is ICAM in immunology?
ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system.
Does the common cold virus have receptors?
(1994) Members of the low density lipoprotein receptor family mediate cell entry of a minor-group common cold virus.
Does a virus need multiple receptors?
Viral receptors function not only as attachment moieties but also as entry factors, coordinators of viral trafficking, and activators of signaling events, and in many cases, viruses utilize multiple receptors to carry out different functions within the virus life cycle.
What is ICAM-1 and how will it be used to fight the cold?
As HRV receptor, ICAM-1 positions the virus to within striking distance of the membrane, and then triggers a conformational change in the virus that ultimately results in delivery of the viral RNA genome into the cytoplasm, across a lipid bilayer.
What does ICAM mean?
Integrated Computer Aided Manufacturing
ICAM
| Acronym | Definition |
|---|---|
| ICAM | Integrated Computer Aided Manufacturing |
| ICAM | Integrated Computer-Aided Manufacturing |
| ICAM | Improved Chemical Agent Monitor |
| ICAM | Interdisciplinary Center for Applied Mathematics |
What receptor does the common cold virus bind to?
The common cold virus rhinovirus 16 contains 60 sites capable of connecting to a receptor, called ICAM-1, on human cells. The virus uses several of these sites to gain entry into the cell.
How does the common cold virus reproduce?
Viruses that cause colds can spread from infected people to others through the air and close personal contact. You can also get infected through contact with stool (poop) or respiratory secretions from an infected person.
What does a virus receptor do?
A virus receptor can be defined as a host cell surface component recognized by the virus as a gateway to entry into the cell.
How do you identify a virus receptor?
The first approach is to identify the receptors by biochemical purification of cellular proteins on the cell surface that bind to the viral antireceptors (ie, viral structural proteins). Affinity purification of plasma membrane proteins using the viral structural proteins as a ligand is feasible.
What does ICAM 2 do?
ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis. This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion.
What is Credential and Access Management?
Identity, credential, and access management (ICAM) comprises the tools, policies and systems that allow an organization to manage, monitor and secure access to protected resources.
Which is the best description of ICAM-1?
DOI: 10.1002/JLB.2MR0220-549R Abstract ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation.
What is the role of ICAM-1 in ocular allergies?
ICAM-1 has an important role in ocular allergies recruiting pro-inflammatory lymphocytes and mast cells promoting a type I hypersensitivity reaction. ICAM-1 is the primary entry receptor for Coxsackievirus A21, an oncolytic virus (brand name Cavatak, being developed by Viralytics ).
What kind of hemorrhage does ICAM 1 cause?
ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.
How is ICAM-1 expressed in respiratory epithelial cells?
ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds . ICAM-1 has an important role in ocular allergies recruiting pro-inflammatory lymphocytes and mast cells promoting a type I hypersensitivity reaction.
