How does EBC-46 work?
How does EBC-46 work?
EBC-46 targets a protein called Protein Kinase C (PKC) that, when inhibited, prevents tumor cells from making proteins that help them live. PKC has been targeted by several compounds, with one, PMA getting a phase I clinical trial (safety and efficacy in a limited group of people with cancer).
Where can Stelfonta be used?
Stelfonta is used for mast cell tumours in the skin, or in mast cell tumours in the tissues just under the skin at or below the elbow or hock.
How does tigilanol tiglate work?
How does Stelfonta work? The active substance in Stelfonta, tigilanol tiglate, stimulates the action of enzymes called protein kinase C which are involved in regulating processes that can help cells grow and survive. By activating these enzymes blood supply to cells gets interrupted, resulting in the death of the cell.
What is Tigilanol Tiglate and how is it produced?
Tigilanol tiglate (TT, also known as EBC-46), is an epoxytigliane isolated from the seed of the native Australian rainforest plant Fontainea picrosperma (Euphorbiaceae)14.
What is Blushwood Berry Good For?
In the pre-clinical trials, an experimental drug produced from the seeds of the rainforest plant, Blushwood tree (Hylandia Dockrillii), has been shown to destroy or shrink tumours in animals, including cats, dogs and horses.
How is Tigilanol Tiglate produced?
Tigilanol tiglate (EBC-46) is a novel short-chain diterpene ester derived from the seeds of the native Australian blushwood tree (Fontainea picrosperma) [6] and is currently in development for the local treatment of a broad range of tumors [[7], [8], [9]].
What are the best drugs for mast cell tumors in dogs?
There are typically two main avenues of chemotherapy for treating mast cell tumors in dogs: the more “traditional” chemotherapy drugs (e.g., CCNU, vinblastine, prednisone), and the newer class of drugs called tyrosine kinase inhibitors (Palladia and Kinavet).
What are Blushwood berries?
Blushwood is a naturally growing tree found mostly in a small area of the Australian Rainforest. In recent years, several studies have been conducted on the chemicals contained in the seed of the Blushwood fruit, mostly EBC 46, for its potential anti-cancer properties.
Is Stelfonta available in the US?
Tigilanol tiglate injection (Stelfonta; Virbac) for treating canine mast cell tumors is now available in veterinarian clinics throughout the United States as an alternative to surgery.
