What is the formula of Diamminedichloroplatinum?
What is the formula of Diamminedichloroplatinum?
cis-Diamminedichloroplatinum Properties (Theoretical)
| Compound Formula | Cl2H6N2Pt |
|---|---|
| Molecular Weight | 300.05104 |
| Appearance | yellow crystals |
| Melting Point | 270 °C |
| Boiling Point | N/A |
What is the charge of cisplatin?
Cisplatin is a diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion….3.1Computed Properties.
| Property Name | Property Value | Reference |
|---|---|---|
| Heavy Atom Count | 5 | Computed by PubChem |
| Formal Charge | 2 | Computed by PubChem |
What is the chemical name of cisplatin?
Cisplatin
| PubChem CID | 5702198 |
|---|---|
| Molecular Formula | PtCl2(NH3)2 or Cl2H6N2Pt |
| Synonyms | cisplatin 14913-33-8 Transplatin trans-Dichlorodiamineplatinum(II) azane;dichloroplatinum More… |
| Molecular Weight | 300.05 |
| Component Compounds | CID 222 (Ammonia) CID 2770 (Platinum(II) chloride) |
How does cisplatin target cancer cells?
Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging DNA and inhibiting DNA synthesis.
What is the element name of PT?
platinum
platinum (Pt), chemical element, the best known and most widely used of the six platinum metals of Groups 8–10, Periods 5 and 6, of the periodic table. A very heavy, precious, silver-white metal, platinum is soft and ductile and has a high melting point and good resistance to corrosion and chemical attack.
What is the IUPAC name of CO NH3 5cl Cl2?
The IUPAC name of the compound [Co(NH3)5Cl]Cl2 is pentaammine chloro cobalt (III) chloride.
What is the oxidation state of platinum in cisplatin?
2+ oxidation state
Platinum complexes play a significant role in the clinical treatment of cancer, with cisplatin, carboplatin, and oxaliplatin (Chart 1) comprising one of the most widely prescribed classes of antineoplastic drugs. These three coordination complexes feature platinum in the 2+ oxidation state.
Is cisplatin platinum based?
Cisplatin, a platinum-based drug, is used in combination chemotherapy for a wide range of solid tumors.
Is cisplatin cell cycle specific?
Cisplatin is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell cycle non-specific. Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments.
What is cisplatin for?
Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.
What kind of metals are used in diamminedichloroplatinum II?
Since the discovery that diamminedichloroplatinum (II) (also known as cisplatin) is effective against certain types of cancer, a large number of other complexes have been synthesized and tested. Some include metals such as titanium, gold, vanadium, osmium, or rhodium.
What is the geometry of cis-diamminedichloroplatinum ( II )?
What is the geometry of cis-diamminedichloroplatinum (II)? From the name, the formula is Pt(NH3)2Cl2. Platinum contributes 2 +, chlorine contributes 2 − overall, and NH3 contributes no charge, hence the complex is neutral.
What is the minimum chloride content for cisplatin?
In solns with an inadequate chloride content, one or both chloride ions in the cisplatin molecule are displaced by water, forming mono- & di-aquo species. The minimum acceptable chloride ion concn is about 0.040 mol/L, the equivalent of about 0.2% sodium chloride. Trissel, L.A. Handbook on Injectable Drugs. 9th ed. Bethesda, MD.
Why are platinum d orbitals bigger than 3d orbitals?
Platinum, being a 5d metal, has d orbitals that are larger than the 3d orbitals, allowing for a more spread out electron density. That decreases the coulombic repulsion energy, which we will call Πc. The more repulsions there are, the more positive Πc is.
