What do you need to know about factor V Leiden?
What do you need to know about factor V Leiden?
Factor V Leiden. Overview. Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Most people with factor V Leiden never develop abnormal clots.
What are the factors that increase the risk of Leiden?
Factors that increase this risk include: Two faulty genes. Immobility. Estrogens. Surgeries or injuries. Non-O blood type.
What are the signs and symptoms of Leiden?
Signs and symptoms may include: 1 Sudden shortness of breath 2 Chest pain when breathing in 3 A cough that produces bloody or blood-streaked sputum 4 Rapid heartbeat
Is the factor V Leiden mutation incomplete penetrance?
Factor V Leiden is an autosomal dominant genetic condition that exhibits incomplete penetrance, i.e. not every person who has the mutation develops the disease.
How old do you have to be to have thrombosis with Factor V Leiden?
The symptoms of factor V Leiden vary among individuals. There are some individuals who have the F5 gene and who never develop thrombosis, while others have recurring thrombosis before the age of 30 years.
What are the non genetic risk factors for Leiden thrombophilia?
Non-genetic risk factors include surgery, long periods of not moving (like sitting on a long airplane ride), birth control pills and other female hormones, childbirth within the last 6 months, non-O blood group, cancer, and injuries (such as bone fractures). [1] [2] [3] [4]
What are the chances of inheriting a Leiden gene?
If you have the heterozygous type, there is a 50% chance that your child will inherit a Factor V Leiden gene from you. There is also a 50% chance that your child will inherit your normal Factor V gene. If you have the homozygous type, your child will inherit a Factor V Leiden gene.
Who are heterozygotes with Factor V Leiden thrombophilia?
Inheritance. People with one copy of the mutation are called heterozygotes. Assuming this person and a person without the mutation have a child, this couple would have a 50%, or 1 in 2 chance of having a child with a single F5 mutation. Factor V Leiden thrombophilia is a relatively common condition.
What happens if you have heterozygous Factor V Leiden mutation?
Information for patients with Heterozygous Factor V Leiden Mutation What is Factor V Leiden? Factor V Leiden is an inherited disorder that makes blood more likely to clot. If you have this disorder you are at risk of developing blood clots, especially in your leg veins. Most people with this disorder have no problems.
