How do you read a CSF report?
How do you read a CSF report?
Interpretation of CSF results from lumbar puncture (LP)
- Appearance: Clear.
- Opening pressure: 10-20 cmCSF.
- WBC count: 0-5 cells/µL. < 2 polymorphonucleocytes [PMN])
- Glucose level: >60% of serum glucose.
- Protein level: < 45 mg/dL.
- Consider additional tests: CSF culture, others depending on clinical findings.
What is the normal range of CSF?
Normal Results CSF total protein: 15 to 60 mg/100 mL. Gamma globulin: 3% to 12% of the total protein. CSF glucose: 50 to 80 mg/100 mL (or greater than two thirds of blood sugar level) CSF cell count: 0 to 5 white blood cells (all mononuclear), and no red blood cells.
What does a CSF test tell you?
CSF testing is performed to evaluate the level or concentration of different substances and cells in CSF in order to diagnose conditions affecting the brain and spinal cord (central nervous system).
What is considered high CSF protein?
The CSF protein content is almost always elevated in bacterial meningitis (Tables 20-1 and 20-2). Several studies have shown that protein levels are increased at least to some degree in more than 95% of patients, and its absolute value is over 80 mg/dl in more than 80% of patients.
What is normal WBC count in CSF?
Cerebrospinal Fluid
| CSF clarity | Clear | |
|---|---|---|
| CSF WBC count | 0–8 leukocytes/mm3 | |
| CSF RBC count | <1 RBC/mm3 | |
| CSF protein | 15–45 mg/dL | 150–450 mg/L |
| CSF culture | Sterile |
What are CSF results?
A CSF analysis is a group of tests that look at your cerebrospinal fluid to help diagnose diseases and conditions that affect the brain and spinal cord. Other names: Spinal Fluid Analysis, CSF Analysis.
How do you interpret CSF IgG?
Cerebrospinal fluid (CSF) IgG synthesis rate indicates the rate of increase in the daily CSF production of IgG in milligrams per day. A result greater than 12 mg/24 hours is elevated. A CSF index greater than 0.85 is elevated and indicative of increased synthesis of IgG.
What does it mean if CSF is high?
Elevated CSF protein is seen in infections, intracranial hemorrhages, multiple sclerosis, Guillain Barré syndrome, malignancies, some endocrine abnormalities, certain medication use, and a variety of inflammatory conditions (Table 3).
Is a CSF leak serious?
A CSF leak is a serious issue that can cause complications such as headaches, meningitis, and seizures.
What can spinal fluid tell you?
A CSF analysis may include tests to diagnose: Infectious diseases of the brain and spinal cord, including meningitis and encephalitis. CSF tests for infections look at white blood cells, bacteria, and other substances in the cerebrospinal fluid.
What does protein in CSF indicate?
An abnormal protein level in the CSF suggests a problem in the central nervous system. Increased protein level may be a sign of a tumor, bleeding, nerve inflammation, or injury. A blockage in the flow of spinal fluid can cause the rapid buildup of protein in the lower spinal area.
Does high protein in CSF mean MS?
Cerebral Spinal Fluid Studies Oligoclonal Immunoglobulin Bands can be identified in the CSF of MS patients via electrophoresis. The overall protein level is also slightly elevated – up to 0.1 g/L. Protein level can be higher if the patient is going through a marked relapse (i.e.,. severe optic neuritis).
What is the reference range for cerebrospinal fluid analysis?
The reference range for cerebrospinal fluid analysis is as follows: Opening pressure – 90-180 mm H2 O (with patient lying in lateral position) Appearance and color – Clear, colorless Antibodies, viral DNA – None Bacteria (Gram stain, culture, VDRL) – Negative Blood cell count and differential – White blood cells: < 5 (all mononuclear); Red bl…
How is cerebrospinal fluid used in the central nervous system?
Analysis of cerebrospinal fluid is used in the diagnosis of a wide variety of diseases and conditions affecting the central nervous system. CSF analysis includes measurement of normal CSF compounds (eg, proteins, glucose), as well as examining for abnormal elements (eg, cells, pathogens, abnormal proteins, serology).
What causes the presence of banding in the cerebrospinal fluid?
Although detection of oligoclonal bands is most often associated with multiple sclerosis, other causes of oligoclonal banding should be excluded. Multiple myeloma and other monoclonal gammopathies, as well as some viral infections, are characterized by the presence of immunoglobulin banding in serum.
