What is acantholytic dyskeratosis?
What is acantholytic dyskeratosis?
Acantholytic dyskeratosis is a histopathologic pattern defined by a hyperkeratotic and parakeratotic epidermis with intraepidermal clefts containing acantholytic and dyskeratotic keratinocytes.
What is Suprabasilar acantholysis?
Suprabasal acantholysis, a common feature of several inflammatory skin diseases, develops exclusively within the germinative cellular pool of the epidermis. The process induces repair mechanisms by proliferation of cells in the suprabasal layers in whatever conditions it occurs, except in pemphigus vulgaris.
What is Grover disease?
Grover’s disease is a rare, transient skin disorder that consists of small, firm, raised red lesions, most often on the skin of the chest and back. Diagnosis of this disorder becomes apparent under microscopic examination when the loss of the “cement” that holds the skin cells together is observed.
What is satellite cell necrosis?
In some drug reactions, apoptotic keratinocytes may be seen in the basal layer or scattered in the lower layers of the epidermis. In graft versus host disease, the apoptotic keratinocytes are seen in association with one or two adjacent lymphocytes in the basal layer and are referred to as ‘satellite cell necrosis’.
What are acantholytic cells?
Acantholysis refers to the loss of attachments between keratinocytes, resulting in the formation of rounded, detached cells within the blister.
What are Acantholytic cells?
What is Hailey Hailey skin condition?
Summary. Hailey-Hailey disease is a rare genetic disorder that is characterized by blisters and erosions most often affecting the neck, armpits, skin folds and genitals. The lesions may come and go and usually heal without scarring. Sunlight, heat, sweating and friction often aggravate the disorder.
Is Grover’s disease curable?
There is no cure for Grover’s disease and treatment is usually based on a person’s symptoms. Affected individuals are usually advised to avoid strenuous exercise and excessive sun exposure, as sweating and heat may induce more itchy spots.
How often are keratinocytes replaced?
In humans, it is estimated that keratinocytes turn over from stem cells to desquamation every 40–56 days, whereas in mice the estimated turnover time is 8–10 days.
Does Grover’s disease go away?
The condition has no cure. In some cases, Grover’s disease may last a few months and then disappear. In others, it may continue on and off for years. Treatment is geared toward relieving the intense itching and rash that accompany this disorder.
Where does acantholysis occur in the human body?
The acantholysis or cleavage in this disease occurs above the basal layer of the epithelium, typically leaving a layer of basal cells with rounded tops, reminiscent of tombstones (Fig. 4.75B and C ). The latter acantholytic cells, called Tzanck cells, are best seen in the smear sample of a fresh blister (Tzanck test).
Where to find acantholytic cells in a blister?
The latter acantholytic cells, called Tzanck cells, are best seen in the smear sample of a fresh blister (Tzanck test).
Where does acantholytic squamous cell carcinoma of the skin appear?
Acantholytic Squamous Cell Carcinoma of Skin may appear as skin lesions, commonly on sun-exposed areas, mostly the head and neck region. The lesions may ulcerate and cause scarring of skin
What kind of cancer is associated with acantholysis?
This syndrome is manifested by ulcerative and blistering mucocutaneous lesions with acantholysis; it is primarily associated with lymphoma (Chapters 191 and 192Chapter 191Chapter 192), other lymphoproliferative diseases, and thymic cancers.
