How long is BOTOX good for after reconstitution?

Ideally you will want to use the reconstituted vial of botulinum toxin within 3 weeks, however it can last up to eight weeks when stored properly in the fridge (Hexcel et al 2003).

What is the standard dilution for BOTOX?

The recommended dose is 100 Units of BOTOX, and is the maximum recommended dose. The recommended dilution is 100 Units/10 mL with preservative-free 0.9% Sodium Chloride Injection, USP (see Table 1).

Does BOTOX require reconstitution?

BOTOX® Cosmetic dilution and reconstitution processes are the same for moderate to severe forehead lines, lateral canthal lines, and glabellar lines. Note: once open and reconstituted, use within 24 hours, because product and diluent do not contain a preservative.

How do you store BOTOX after reconstitution?

BOTOX should be administered within 24 hours after reconstitution. During this time period, reconstituted BOTOX should be stored in a refrigerator (2° to 8°C).

What happens if you over dilute Botox?

Overly diluted injections, which can lower a doctor’s costs, can be ineffective and raise the risk of complications, such as having a droopy eyelid. “There is a lot of sophistication and subtlety to this,” Kinney says. “It’s not just taking a needle and poking it into someone’s face and pushing the plunger.”

What happens if you use old Botox?

And if you’re already using Botox, over-application could make it worse. “Overuse of Botox can cause the muscles to become so weak that they can’t support the flesh.” The results can look unnatural, and even worse, be painful.

How many mL is 200 units of Botox?

The reconstituted solution of BOTOX (200 Units/30 ml) is injected via a flexible or rigid cystoscope, avoiding the trigone and base. The bladder should be instilled with enough saline to achieve adequate visualisation for the injections and avoid backflow of the product, but over-distension should be avoided.

What is Botox reconstitution?

Allergan advocates 100 U of BOTOX® diluted in 2 cc of preservative-free normal saline, which results in a concentration of 5 U/per 0.1 mL. Reconstitution is performed using a vial of BOTOX®, which must remain upright. A 21-gauge, 2-inch needle is attached to a 5 mm syringe.

Is Botox liquid or powder?

Botox comes as a barely visible powder at the bottom of a glass vial. In order to turn it into the liquid we inject, we reconstitute it into solution.

Does Botox get diluted?

BOTOX needs to be partially diluted with saline before being administered. Professionals know the correct mixture to keep the BOTOX both strong AND safe; other places that lack expertise or scruples will heavily dilute the treatment with saline, making it weaker and less effective.

Can reconstituted Botox be frozen?

Botulinum toxin type A may be safely used after being reconstituted and then frozen up to 4 weeks and perhaps up to 8 weeks without a significant loss of effectiveness or additional side effects in the treatment of laryngeal adductor spasmodic dysphonia.

Can you reconstitute Botox with sterile water?

TIP: Always use bacteriostatic normal saline as the diluent as per manufacturer guidance. Reconstituting with sterile water can cause the client great discomfort during treatment.

How is the reconstitution of Botox done?

Reconstituted BOTOX® should be clear, colorless, and free of particulate matter. Insert the needle straight into the vial, then tilt the vial at a 45° angle. Slowly inject the saline into the BOTOX® neurotoxin vial. Vacuum is present in the vial, which demonstrates that the sterility of the vial is intact.

How big of a needle do you need for Botox reconstitution?

A 30-gauge, 0.5 inch needle is recommended. Use of the BOTOX®reconstitution stickers allows you to easily record the date and time of reconstitution, amount of diluent added, and the resulting dose to be administered when BOTOX®neurotoxin is reconstituted prior to a treatment session.

What’s the best way to draw Botox fluid?

Draw the fluid into the injection syringe by placing the needle into the bottom corner of the vial for full extraction. Do not invert the vial. Disconnect the injection syringe from the vial and attach an appropriate needle for injection. A 30-gauge, 0.5 inch needle is recommended.

What’s the correct way to inject Botox neurotoxin?

Insert the needle straight into the vial, then tilt the vial at a 45° angle. Slowly inject the saline into the BOTOX® neurotoxin vial. Vacuum is present in the vial, which demonstrates that the sterility of the vial is intact.