Is hypogammaglobulinemia primary or secondary?
Is hypogammaglobulinemia primary or secondary?
Hypogammaglobulinemia can be primary (congenital) or secondary. It can present in childhood and in adults, and can affect both sexes. Primary hypogammaglobulinemia may have a delay of several years between clinical presentation and diagnosis. The most common cause is common variable immunodeficiency (CVID).
What are the symptoms of hypogammaglobulinemia?
Hypogammaglobulinemia is a problem with the immune system that prevents it from making enough antibodies called immunoglobulins….Which symptoms you or your child has will depend on what infections you get, but they can include:
- coughing.
- sore throat.
- fever.
- ear pain.
- congestion.
- sinus pain.
- diarrhea.
- nausea and vomiting.
What is the cause of hypogammaglobulinemia?
Hypogammaglobulinemia may result from a variety of primary genetic immune system defects, such as common variable immunodeficiency, or it may be caused by secondary effects such as medication, blood cancer, or poor nutrition, or loss of gamma globulins in urine, as in nonselective glomerular proteinuria.
What is hypogammaglobulinemia treatment?
The standard treatment for hypogammaglobulinemia is IgG replacement, which may be given intravenously or subcutaneously.
Does multiple myeloma have Hypogammaglobulinemia?
Hypogammaglobulinemia may be congenital or acquired. Amongst the acquired causes are multiple myeloma and primary amyloidosis. Panhypogammaglobulinemia can occur in about 10% of cases of multiple myeloma.
What are secondary immunodeficiencies?
Secondary immunodeficiencies are the result of disease or other environmental factors weakening the immune system.
Is hypogammaglobulinemia a lifelong?
Many may fail to properly reconstitute B cell function and have persistent antibody deficiency. In all of these situations, spontaneous improvement in the course of the disease is not expected, and IgG therapy must be lifelong.
What is an example of secondary immunodeficiency disease?
Examples of secondary immunodeficiency disorders include: AIDS. cancers of the immune system, like leukemia. immune-complex diseases, like viral hepatitis.
What are the reason for secondary immunodeficiency?
Other causes of secondary immunodeficiency include: severe malnutrition, certain chronic diseases such as diabetes, immunosuppressive medication or chemotherapy, certain cancers such as leukemia, and the absence of the spleen (sometimes the spleen must be removed because of trauma, for example).
