What is colistin sulfate used for?
What is colistin sulfate used for?
Colistin Sulphate is used in the treatment of severe bacterial infections. It is used to treat certain types of serious infections which are not responding to other antibiotics. Colistin Sulphate is an antibiotic. It kills bacteria by destroying the bacterial cell membrane.
What kind of antibiotic is colistin?
Colistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter.
How do you use colistin sulfate?
USES: This medication is used to treat certain stomach, bowel and digestive tract infections. HOW TO USE: Take this medication by mouth as directed. This may be taken with food if stomach upset occurs. Shake well before pouring each dose.
Why is colistin toxic to humans?
Renal toxicity is the most common adverse effect of colistin treatment because the drug is excreted primarily by the kidneys and elevated blood levels may further impair renal function.
Why is colistin banned in India?
India: Central Government Bans Use of Colistin In Livestock To Tackle Anti-Microbial Resistance. The regulatory measure was taken to ensure the cautious use of anti-microbial agents in humans and animals to tackle the issue of anti-microbial resistance.
Why is colistin banned?
jpg. A new study by Chinese scientists suggests the country’s formal ban on the use of the last-resort antibiotic colistin for growth promotion in livestock has had a significant short-term impact on colistin resistance in China.
How is colistin sulfate used in the medical field?
Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii . It has been used to study hephrotoxicity in the rat kidney , and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa .
Where is colistin found in the human body?
Animal studies indicate that colistin reversibly binds to and persists in body tissues such as the liver, kidneys, lung, heart, and muscle. Colistin is reportedly more than 50% bound to serum proteins. Colistimethate sodium and metabolites of the drug are excreted mainly by the kidneys via glomerular filtration.
What does colistin do to the bacterial membrane?
Colistin acts like a cationic detergent and binds to and damages the bacterial cytoplasmic membrane of susceptible bacteria. Damage to the bacterial cytoplasmic membrane alters the osmotic barrier of the membrane and causes leakage of essential intracellular metabolites and nucleosides.
What are the side effects of colistimethate sodium?
Nephrotoxicity and neurotoxicity are the most serious adverse effects of colistimethate sodium and are most likely to occur when the drug is used in higher than recommended dosages or in patients with impaired renal function.
