What does CAV1 stand for?
What does CAV1 stand for?
Abbreviation for canine adenovirus 1.
Where are L type calcium channels found?
skeletal muscle
Only two types have been found in the cardiovascular system—the L-type and the T-type. L-Type calcium channels are present in cardiac and skeletal muscle, in vascular smooth muscle, and in certain secretory cells of the neuroendocrine system.
What is the difference between L-type and T-type calcium channels?
The L-type calcium channel is responsible for normal myocardial contractility and for vascular smooth muscle contractility. In contrast, T-type calcium channels are not normally present in the adult myocardium, but are prominent in conducting and pacemaking cells.
What are L-type calcium channels do?
L-type calcium channels are responsible for the excitation-contraction coupling of skeletal, smooth, cardiac muscle, and for aldosterone secretion in endocrine cells of the adrenal cortex.
What is the function of caveolin 1 in the caveolae?
Caveolin-1 (Cav-1), an integral membrane protein expressed in two isoforms (Cav-1α and Cav-1β), is a major component of caveolae membranes in vivo. It has been implicated in regulating several signaling pathways and mediating intracellular processes, specifically as a negative regulator in several mitogenic pathways and in oncogenesis.
Which is the gene thatcodes for Caveolin 1?
Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.
What are the functions of Cav1 scaffolding domain?
Cav1 contains a scaffolding domain that has the ability to bind various classes of signaling proteins such as G-protein subunits, receptor and nonreceptor tyrosine kinases, endothelial nitric oxide synthase (eNOS), and small GTPases (Okamoto et al., 1998;
How does caveolin binding affect src tyrosine kinases?
“Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases”.
