What was the main result of the accord BP trial?
What was the main result of the accord BP trial?
The ACCORD lipid trial involved 5,518 participants. Researchers found that, overall, the combination therapy was safe, but it did not lower the risk of heart attack, stroke, or death from cardiovascular disease more than statins alone.
Does fenofibrate reduce cardiovascular risk?
Fenofibrate significantly reduced CVD events in those with low HDL cholesterol or hypertension. The largest effect of fenofibrate to reduce CVD risk was observed in subjects with marked dyslipidemia in whom a 27% relative risk reduction (95% CI 9–42, P = 0.005; number needed to treat = 23) was observed.
Is fenofibrate better than statin?
Fenofibrate is more effective than statins at increasing HDL cholesterol levels, similar to atorvastatin and rosuvastatin at reducing triglyceride levels, but less effective than statins at lowering LDL cholesterol levels. Available as oral tablets in two strengths, 54mg, and 160mg.
What is Accord study?
In summary, the ACCORD Study was a double 2×2 factorial design with factors consisting of: intensive versus standard glycemic control, intensive versus standard blood pressure control, and blinded fenofibrate or placebo in combination with simvastatin to maintain desirable LDL-C levels.
When was accord trial published?
ACCORD Clinical Trial Publishes Results, June 6, 2008 – National Institutes of Health (NIH)
Does high blood pressure indicate diabetes?
Having hypertension appears to increase the risk of type 2 diabetes, and having type 2 diabetes increases the risk of hypertension. Also, having one or both conditions increase the risk of various complications, including: heart attack or stroke.
What is Advance trial?
ADVANCE (Action in Diabetes and Vascular Disease-PreterAx and DiamicroN Controlled Evaluation) is an ongoing large-scale prospective randomised clinical trial aimed at investigating the effects of blood pressure lowering and intensive blood glucose control in high risk diabetic patients on major macrovascular and …
What is Vadt trial?
The primary goal of the Veterans Affairs Diabetes Trial (VADT) was to compare the effects of intensive and standard glucose control on cardiovascular events.
Who are the patients in the accord trial?
ACCORD is the first large clinical trial to compare the cardiovascular effects of a statin (simvastatin) and placebo, or inactive pill, to combination therapy of a statin (simvastatin) and a fibrate (fenofibrate) in high-risk adults with type 2 diabetes. The ACCORD lipid trial involved 5,518 participants.
When do the results of the accord trial come out?
The results of the ACCORD blood pressure and lipid clinical trials appear online in the New England Journal of Medicine (NEJM) today and will be in the April 29, 2010, NEJM print edition. The results are also being presented today at the American College of Cardiology’s 59th annual scientific session in Atlanta.
Is the landmark accord trial a clinical trial?
Landmark ACCORD Trial Finds Intensive Blood Pressure and Combination Lipid Therapies do not Reduce Combined Cardiovascular Events in Adults with Diabetes. A clinical trial was needed to determine the effects of treatment to reach this normal systolic blood pressure level in these patients.
How did the accord blood sugar trial work?
All participants were enrolled in the ACCORD blood sugar treatment clinical trial and maintained good control of blood sugar levels during the study. In addition, participants were enrolled in either the blood pressure trial or the lipid trial and were treated and followed for an average of about five years.
