What is the structure of diclofenac?

What is the structure of diclofenac?

C14H11Cl2NO2
Diclofenac/Formula

What is the crystal structure of diclofenac sodium?

Diclofenac is a monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position. It has a role as a non-narcotic analgesic, an antipyretic, an EC 1.14….1.3Crystal Structures.

What functional groups are present in diclofenac?

Diclofenac has a carboxylic acid functional group and is rapidly and completely absorbed after oral administration.

Is diclofenac a COX 1 or COX 2 inhibitor?

Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. Mol Carcinog.

How is diclofenac metabolised?

Diclofenac undergoes oxidative metabolism to hydroxy metabolites as well as conjugation to glucuronic acid, sulfate, and taurine. The primary metabolite is 4′-hydroxy diclofenac which is generated by CYP2C9. This metabolite is very weakly active with one thirtieth the activity of diclofenac.

How is diclofenac metabolized?

Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine.

What is the Iupac name of diclofenac sodium?

(diclofenac sodium enteric-coated tablets) is a benzene-acetic acid derivative. Voltaren is available as delayed-release (enteric-coated) tablets of 75 mg (light pink) for oral administration. The chemical name is 2-[(2,6-dichlorophenyl)amino] benzeneacetic acid, monosodium salt.

What is the chemical name of diclofenac?

2-[2-(2,6-dichloroanilino)phenyl]acetic acid
Diclofenac/IUPAC ID

What is the mechanism of action for diclofenac?

As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.

Is diclofenac selective or non-selective?

Conventional NSAIDs, like diclofenac, ibuprofen, and naproxen, are non-selective COX inhibitors, blocking the production of both physiologic and inflammatory prostaglandins.

Does NSAIDs inhibit COX-1 and 2?

NSAIDs inhibit the rate-limiting enzyme cyclooxygenase (COX) in prostaglandin synthesis and two COX isoforms have been identified, COX-1 and COX-2. The COX-1 isoform produces cytoprotective prostaglandins and is present in most tissues, including the gastrointestinal mucosa, kidneys, and platelets.

Is diclofenac selective or nonselective?

Is diclofenac a controlled substance?

No, diclofenac is not a controlled substance. It is a non steroidal anti-inflammatory drug. It is not a controlled substance.

What is diclofenac SOD EC 75mg tablets?

Diclofenac sodium 75mg ec is an extended release non-steroid anti-inflammatory drug (NSAID) usually used for gout attacks.

What is diclofenac diethylamine?

Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. For research use only. We do not sell to patients.