What does positive for PAX8 mean?
What does positive for PAX8 mean?
PAX8-positive, calretinin-negative staining appears to be highly specific and sensitive for detecting metastatic ovarian serous carcinoma in cytological preparations and may prove useful for distinguishing these cells from mesothelial cells in fluid cytology (32).
What are reactive mesothelial cells?
Reactive Mesothelial Cells. Reactive mesothelial cells can be found when there is an infection or an inflammatory response present in a body cavity. This condition can be due to the presence of a bacterial, viral, or fungal infection. It can also be the result of trauma or the presence of metastatic tumor.
What is positive peritoneal washings?
Peritoneal washings are obtained during surgery, most often for gynecologic and primary peritoneal cancers. Washings are particularly important in women with cancers of the ovary and fallopian tube because a positive result upstages the disease.
What are pelvic washings?
Pelvic washing (PW) is a surgical procedure used to assess the presence of intraperitoneal metastases for gynecologic and nongynecologic malignancies within the pelvis, paracolic gutters, and/or subdiaphragmatic space.
Are mesothelial cells in ascites fluid?
Human peritoneal mesothelial cells (HPMCs) form the peritoneal lining and serve as a protective anatomical barrier. They are among the most abundant cell type in ascites from patients with OC [13].
Are mesothelial cells malignant?
Mesothelial tumors can start in any of these linings. These tumors can be cancer (malignant) or not cancer (benign). A cancer tumor of the mesothelium is called a malignant mesothelioma. This is often shortened to just mesothelioma.
What is peritoneal cytology?
Abstract. Peritoneal washing cytology (PWC) is a useful indicator of ovarian surface involvement and peritoneal dissemination by ovarian tumours. It may identify subclinical peritoneal spread and thus provide valuable staging and prognostic information, particularly for non-serous ovarian tumours.
What are washings?
Often washings . any liquid that has been used to wash something. matter removed or carried off in washing something or by the force of water: The washings from numerous spring floods had clogged the mouth of the river.
What is PAX8 gene?
The PAX8 gene belongs to a family of genes that play critical roles in the formation of tissues and organs during embryonic development. The PAX gene family is also important for maintaining the normal function of certain cells after birth.
What is the expression of PAX8 in normal tissues?
Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study PAX8 is a nephric-lineage transcription factor and is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and Müllerian system. PAX8 is shown to be expressed in a high percentage of kidney and ovarian carcinomas.
How is PAX8 expressed in the Mullerian system?
PAX8 is a nephric-lineage transcription factor and is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and Müllerian system. PAX8 is shown to be expressed in a high percentage of kidney and ovarian carcinomas. Limited information is known about the specificity of PAX8 in various neoplastic tumors.
How are PAX8 antibodies cross react with PAX5?
Polyclonal PAX8 antibodies are known to cross react with PAX5 (e.g. B cell lymphocytes, B cell lymphoma) and PAX6 (e.g. pancreatic islet cells, neuroendocrine tumors of select sites) N terminal DNA binding domain is highly conserved among the PAX family of transcription factors
Where can I find the pathology outline PAX8?
PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainspax8.html. Accessed September 12th, 2021. Nuclear marker with expression in epithelial neoplasms of thyroid, thymic, ovarian, endometrial, endocervical, fallopian tube and renal origin
