Is SOX9 a transcription factor?
Is SOX9 a transcription factor?
The SOX9 protein attaches (binds) to specific regions of DNA and regulates the activity of other genes, particularly those that control skeletal development and sex determination. On the basis of this action, the SOX9 protein is called a transcription factor.
What regulates SOX9?
TGF-β, BMPs, and/or hedgehog signaling positively regulate SOX9 expression during the initial stages of chondrogenic differentiation. Recent studies suggested that Hippo signaling also contributes to cartilage and bone development via crosstalk with various growth factors, hormones, and/or transcription factors[38,39].
Which transcription factor is essential for formation of chondrocytes?
Sox9
Our results identify Sox9 as the first transcription factor that is essential for chondrocyte differentiation and cartilage formation.
Do chondrocytes make cartilage?
Chondrocytes are the cells responsible for cartilage formation, and they are crucial for the process of endochondral ossification, which is useful for bone development. Also, by mimicking skeletal development chondrocytes play a critical role in fracture repair.
Where is Sox9 expressed?
Sox9 is expressed predominantly in mesenchymal condensations throughout the embryo before and during the deposition of cartilage, consistent with a primary role in skeletal formation. Interspecific backcross mapping has localized mouse Sox9 to distal chromosome 11.
Is Sox9 on the Y chromosome?
It also interacts with a few other genes to promote the development of male sexual organs. The process starts when the transcription factor Testis determining factor (encoded by the sex-determining region SRY of the Y chromosome) activates SOX-9 activity by binding to an enhancer sequence upstream of the gene.
What are hypertrophic chondrocytes?
Hypertrophic chondrocytes are specialized cells consid- ered to be the end state of the chondrocyte differentiation pathway, and are essential for bone growth. They are characterized by expression of type X collagen encoded by the Col10a1 gene, and synthesis of a calcified cartilage matrix.
Whats is cartilage?
Cartilage is the main type of connective tissue seen throughout the body. It serves a variety of structural and functional purposes and exists in different types throughout our joints, bones, spine, lungs, ears and nose.
What are cartilage chondrocytes?
Chondrocytes (/ˈkɒndrəsaɪt, -droʊ-/, from Greek χόνδρος, chondros = cartilage + κύτος, kytos = cell) are the only cells found in healthy cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans.
What is SOX9 a marker for?
SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma. Published: 26 July 2016.
Which chromosome is SOX9 located?
Campomelic dysplasia (CD) is a skeletal malformation syndrome frequently accompanied by 46,XY sex reversal. A mutation-screening strategy using SSCP was employed to identify mutations in SOX9, the chromosome 17q24 gene responsible for CD and autosomal sex reversal in man.
What chromosome is Sox9?
A mutation-screening strategy using SSCP was employed to identify mutations in SOX9, the chromosome 17q24 gene responsible for CD and autosomal sex reversal in man.
