Is meropenem contraindicated in seizures?
Is meropenem contraindicated in seizures?
Practice Guidelines for the management of Infectious disease in the USA recommended meropenem over imipenem due to decreases risk of seizure with the former. However, there is inconsistency in the literature regarding whether there is a difference in the seizure potential between the two carbapenems.
Can imipenem cause seizures?
Imipenem has been reported to cause CNS toxicity including seizures in 1.5-10% of patients.
Which carbapenem has the highest seizure risk?
In general, the incidence of seizures associated with carbapenems is as follows, in order of decreasing frequency: Meropenem (0.7%) [6], ertapenem (0.5%) [7], and imipenem (0.4%) [8], according to FDA-approved labeling; but compared to other carbapenems, the highest seizure rate has occurred with the use of imipenem ( …
Can meropenem lower seizure threshold?
Bacterial meningitis guidelines published by the Infectious Diseases Society of America recommend meropenem over imipenem due to decreased risk of seizure with meropenem.
Who should not take meropenem?
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of meropenem injection in children 3 months of age and older with complicated skin and skin structure infections and bacterial meningitis, and for children with intra-abdominal infections.
When should you not use meropenem?
Who should not take MEROPENEM?
- diarrhea from an infection with Clostridium difficile bacteria.
- decreased blood platelets.
- lesion of the brain.
- seizures.
- chronic kidney disease stage 4 (severe)
- chronic kidney disease stage 5 (failure)
- kidney disease with likely reduction in kidney function.
Can meropenem cause seizures?
There are numerous reports of seizure activity associated with imipenem-cilastatin, with seizure rates ranging from 3-33%. For meropenem, doripenem, and ertapenem, the seizure rate for each agent is reported as less than 1%.
Does imipenem lower seizure threshold?
Key Words: Critical illness and seizure risk—Imipenem— Epilepsy—Antibiotic adverse events. Some drugs, including several antibiotics, lower the seizure threshold. The -lactam antibiotic imipenem has been associated with a 3% incidence of seizures (1).
Can meropenem cause seizure?
What are side effects of meropenem injection?
SIDE EFFECTS: Swelling, redness, pain, or soreness at the injection site may occur. This medication may also infrequently cause upset stomach, headache, nausea, vomiting, constipation, or diarrhea. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Is imipenem safe in epileptics?
Despite experimental data to suggest action of imipenem on the glutamate/N-methyl-d-aspartate receptor, or interference with binding to the gamma-aminobutyric acid receptor, and early clinical studies that warned against its use because of seizure risk, we found that careful use of this antibiotic is safe.
Which is better for seizures meropenem or imipenem?
Conclusions: The absolute risk of seizures with carbapenems was low, albeit higher than with non-carbapenem antibiotics. Although imipenem was more epileptogenic than non-carbapenem antibiotics, there was no statistically significant difference in the imipenem versus meropenem head-to-head comparison.
Are there any carbapenem antibiotics that cause seizures?
The risk of seizures among the carbapenems: a meta-analysis The absolute risk of seizures with carbapenems was low, albeit higher than with non-carbapenem antibiotics. Although imipenem was more epileptogenic than non-carbapenem antibiotics, there was no statistically significant difference in the imipenem versus meropenem head-to-head comparison.
How is imipenem different from other carbapenems?
This difference was largely attributed to imipenem as its use was associated with an additional 4 patients per 1000 with seizure (95% CI 0.002, 0.007) compared with non-carbapenem antibiotics, whereas none of the other carbapenems was associated with increased seizure.
Which is more epileptogenic meropenem or carbapenem?
Although imipenem was more epileptogenic than non-carbapenem antibiotics, there was no statistically significant difference in the imipenem versus meropenem head-to-head comparison. Carbapenem antibiotics possess a broad antimicrobial spectrum and are commonly used in complicated and serious bacterial infections.
