Is LIF a cytokine?
Is LIF a cytokine?
LIF is a pleiotrophic cytokine of the 4-α-helix bundle family that includes interleukin-6 (IL-6), LIF, oncostatin M, ciliary neurotrophic factor, IL-11 and cardiotrophin-1.
What is the role of LIF?
LIF regulates the embryonic stem cell self-renewal and is an indispensable factor to maintain mouse embryonic stem cell pluripotency. Furthermore, LIF plays an important role in embryonic implantation.
What is LIF protein?
Leukemia Inhibitory Factor (LIF) belongs to the interleukin-6 cytokine family. LIF also has the capacity to induce terminal differentiation of leukemic cells, hematopoietic differentiation in myeloid leukemia cells, neuronal cell differentiation, and stimulate acute-phase protein synthesis in hepatocytes.
What is the LIF gene?
LIF (LIF Interleukin 6 Family Cytokine) is a Protein Coding gene. Diseases associated with LIF include Leukemia and Myeloid Leukemia. Among its related pathways are Innate Immune System and Interleukin-6 family signaling.
Is LIF a compound?
Lithium fluoride is an inorganic compound with the chemical formula LiF. It is a colorless solid, that transitions to white with decreasing crystal size. Although odorless, lithium fluoride has a bitter-saline taste.
What is the chemical name for lif?
Lithium fluoride
Lithium fluoride (LiF) is used chiefly as a fluxing agent in enamels and glasses.
What is Lif in human body?
Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.
What is LIF in human body?
What is LIF stem cells?
LIF (leukaemia inhibitory factor) is commonly used to maintain mouse embryonic stem cells in an undifferentiated state. These cells spontaneously differentiate when allowed to aggregate in the absence of LIF, forming embryoid bodies in which early embryonic cell lineages develop.
Is LiF ionic or molecular?
LiF is lithium fluoride. This is an example of a binary ionic compound, which consists of two elements, a cation and anion. Since lithium, the metal has a plus one charge, and fluoride, a nonmetal, has a negative charge, these two ions are held together through an ionic bond.
Is LiF an anion or cation?
Molecules with Li in CCCBDB
| Molecule | Name | Cation |
|---|---|---|
| LiF | lithium fluoride | LiF+ |
| LiNe+ | ||
| NaLi | lithium sodium | NaLi+ |
| LiMg | Lithium magnesium |
Is LiF toxic?
Acute toxicity: Toxic if swallowed. Skin irritation or corrosion: Causes skin irritation. Eye irritation or corrosion: Causes serious eye irritation.
Where does the IL-6 cytokine LIF bind?
Like other IL-6 family cytokines, LIF is a four alpha-helix bundle cytokine that signals through a receptor complex containing the gp130 receptor subunit. LIF binds with high affinity to both LIF R and gp130, which form a heterodimeric receptor complex.
How does the Leukemia inhibitory factor ( LIF ) work?
Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth.
What are the signaling pathways of leukemia inhibitory factor?
Overview of Leukemia Inhibitory Factor (LIF) Signaling Pathways Leukemia inhibitory factor (LIF) is a member of the IL-6 cytokine family, which also includes IL-6, IL-11, IL-27 p28/IL-30, IL-31, Oncostatin M (OSM), Cardiotrophin-like cytokine (CLC), Ciliary neurotrophic factor (CNTF), Cardiotrophin-1 (CT-1), and Neuropoietin.
Which is the most pleiotropic member of the interleukin-6 family?
Leukemia inhibitory factor (LIF) Leukemia inhibitory factor (LIF) is the most pleiotropic member of the interleukin-6 family of cytokines. It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M, cardiotrophin1 (CT1) and c …
