What is chloramphenicol resistance gene?
What is chloramphenicol resistance gene?
The chloramphenicol resistance gene (pp-cat) was cloned from a transferable R plasmid of Pasteurella piscicida, pSP9351, and the sequence of the gene was determined. Subcloning and deletion analysis localized the resistance gene, pp-cat, to within a 2.3 kb HincII-BamHI fragment.
Is there any resistance to chloramphenicol?
Chloramphenicol resistance occurs and is mediated by a bacterial enzyme, chloramphenicol acetyltransferase (CAT), which inactivates the drug.
What causes chloramphenicol resistance?
The most common mechanism of resistance to chloramphenicol in bacteria is its enzymatic inactivation by acetylation mainly via acetyltransferases or, in some cases, by chloramphenicol phosphotransferases (1, 56).
What bacteria is resistant to chloramphenicol?
4 Bacterial resistance to chloramphenicol and florfenicol
| Gene designation(s) | Bacterial source(s) | % Identity |
|---|---|---|
| AAa | ||
| catII | Haemophilus influenzae | [24] |
| catII | Agrobacterium tumefaciens, Escherichia coli | [24] |
| cat | Photobacterium damselae subsp. piscicida | [35] |
What is resistance gene?
Resistance genes (R-Genes) are genes in plant genomes that convey plant disease resistance against pathogens by producing R proteins. The main class of R-genes consist of a nucleotide binding domain (NB) and a leucine rich repeat (LRR) domain(s) and are often referred to as (NB-LRR) R-genes or NLRs.
Is chloramphenicol bacteriostatic or bactericidal?
Chloramphenicol is bactericidal at clinically achievable concentrations against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis. It is bacteriostatic against gram-negative bacilli of the family Enterobacteriaceae and against Staphylococcus aureus.
What is an example of genetic resistance?
Some of the best examples of genetic resistance involve the tolerance of certain bacteria to antibiotics and of certain pests to pesticides.
How are resistance genes acquired?
Bacteria can acquire antibiotic resistance genes from other bacteria in several ways. By undergoing a simple mating process called “conjugation,” bacteria can transfer genetic material, including genes encoding resistance to antibiotics (found on plasmids and transposons) from one bacterium to another.
What is the structure of chloramphenicol?
C11H12Cl2N2O5
Chloramphenicol/Formula
