What causes Leydig cell hyperplasia?
What causes Leydig cell hyperplasia?
Identifiable causes of Leydig’s cell hyperplasia include cryptorchidism, congenital adrenal hyperplasia, hCG production by germ cell tumors or choriocarcinoma, pituitary abnormalities, Klinefelter’s syndrome, exogenous hCG therapy, and antiandrogen therapy for prostate cancer [1,2,3, 6, 8].
What do Leydig cells do in females?
Testicular Leydig cells (LC) regulate the proper development of male individuals, both during fetal life (fetal LC) and puberty (adult LC). In the ovaries of adult women, there are cells that are very similar to Leydig cells, the ovarian hilus cells (OHC), which also produce testosterone.
How is Leydig cell hyperplasia treated?
There is no standard treatment for LCH. Treatment depends on the features and severity in each person and may include hormone therapy ; surgery for undescended testes, removal of testes, or to correct genital differences; and assisted reproductive technology for infertility.
Does hCG damage Leydig cells?
Repeated hCG treatment raises H2O2 levels, induces apoptosis of Leydig and germ cells, and decreases testosterone release in rat testis (Gautam et al. These observations showed that repeated and/or excessive hCG treatment seems to heavily damage steroidogenesis in Leydig cells.
Can females have Leydig cell hypoplasia?
Leydig cell hypoplasia does not occur in biological females as they do not have either Leydig cells or testicles.
Do Leydig cells secrete testosterone?
Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testes. The best-established function of Leydig cells is to produce the androgen, testosterone, under the pulsatile control of pituitary luteinizing hormone (LH) (9).
Are Leydig cells required for sperm production?
In males the interstitial cells of Leydig, located in the connective tissue surrounding the sperm-producing tubules of the testes, are responsible for the production and secretion of testosterone.
Does Leydig cells produce estrogen?
In the adult testis, estrogen is synthesized by Leydig cells and the germ cells, producing a relatively high concentration in rete testis fluid. Estrogen receptors are present in the testis, efferent ductules and epididymis of most species.
Is Leydig cell hypoplasia inherited?
This condition is inherited in an autosomal recessive pattern , which means both copies of the gene in each cell have mutations.
Do females have Leydig cells?
The Leydig cells, also located in the testes, release a male sex hormone. These cells are also found in a woman’s ovaries, and in very rare cases lead to cancer. SLCT starts in the female ovaries, mostly in one ovary.
Do Leydig cells produce progesterone?
In 2012, the BLTK-1 Leydig cell line was developed from a testicular tumor [42]. These cells retain functional LHCGR-mediated steroidogenesis, producing progesterone, testosterone, and estradiol. The most important is that the cells produce progesterone rather than testosterone.
Do Leydig cells produce estrogen?
Can a Leydig cell hyperplasia cause infertility?
Leydig cell hyperplasia does not affect fertility in all males. Other conditions that can affect Leydig cell function include cancer, cirrhosis of the liver, injury and exposure of the testes to prolonged heat.
What are the nodules on the Leydig cell?
Leydig cell hyperplasia is characterized by multiple nodules occurring on the testes. The condition is usually benign, but may be present with other disorders or conditions. Leydig cell hyperplasia does not affect fertility in all males.
How are Leydig cells related to spermatogenesis?
Thus, Leydig cells and testosterone secretions directly affect and stimulate spermatogenesis (sperm cell development).Here are some conditions the affecting Leydig cells in males. Leydig cell tumors are rare, comprising of only about 3 percent of all testicular tumors.
What kind of pathology is Leydig cell hyperplasia?
Leydig cell hyperplasia is an uncommon benign pathology of the testis. It may be seen in the ovary . Benign. Uncommonly seen in isolation by pathology. Congenital (primary). Cryptorchidism. Advanced age. Adrenal hyperplasia. Excess hCG – exogenous or tumour. Klinefelter’s syndrome. Pernicious anemia. Alcoholism. Infection – syphilis, tuberculosis.
