Is NS1 antigen specific for dengue?

NS1 Ag assay is useful, sensitive and specific for the diagnosis of dengue infection, especially during the acute phase when antibodies are not detectable and the dengue serology was negative. Early diagnosis and timely intervention can reduce the mortality due to severe dengue infection.

Is dengue NS1 test accurate?

The accuracy of the NS1 antigen rapid test is considered high with sensitivity 55%-82% and specificity 97%-100%. Since the NS1 rapid test aims to detect dengue NS1 antigen, it should be performed within 5 days of onset of fever.

Can NS1 be false negative?

False-negative NS1 tests have been reported in dengue serotypes 2 and 4 infections. NS1 tests are also reported to be less sensitive in secondary dengue.

What is the amount of sensibility of NS1 in primary infection?

In primary infections, the InBios NS1 kit demonstrated a higher sensitivity (98.8%) than in secondary infections (83.5%).

When is NS1 detected?

NS1 is detectable during the acute phase of dengue virus infections. NS1 tests can be as sensitive as molecular tests during the first 0-7 days of symptoms. After day 7, NS1 tests are not recommended. A positive NS1 test result is indicative of a dengue infection but does not provide serotype information.

What is the confirmatory test for dengue?

Nucleic acid amplification tests (NAATs) Presence of virus by rRT-PCR or NS1 antigen in a single diagnostic specimen is considered laboratory confirmation of dengue in patients with a compatible clinical and travel history.

What is sensitivity specificity?

Sensitivity refers to a test’s ability to designate an individual with disease as positive. A highly sensitive test means that there are few false negative results, and thus fewer cases of disease are missed. The specificity of a test is its ability to designate an individual who does not have a disease as negative.

How do you read an NS1 test?

Interpretation of results

A positive NS1 test result confirms dengue virus infection without providing serotype information.
A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.

Which test is best for dengue?

Here are the common tests recommended to diagnose dengue:

Dengue NS1 Antigen. This is a blood test to detect the dengue virus early in the course of an infection.
Immunoglobulin M (IgM)
Immunoglobulin G (IgG)
Dengue RNA PCR test.

Which test is more applicable to your patient dengue Duo or dengue NS1?

Dengue IgM/IgG serological test In the later stages of illness, dengue serology is more useful, as NS1 antigen remains detectable for up to only nine days and the patient may thus test negative for dengue.

What is the range of dengue fever?

Reference Range: Dengue Fever Virus Antibody, IgG 1.64 IV or less: Negative – No significant level of detectable dengue fever virus IgG antibody. 1.65-2.84 IV: Equivocal – Questionable presence of antibodies. Repeat testing in 10-14 days may be helpful.

When is NS1 antigen test done?

How should it be used and at what time during infection? NS1 is detectable during the acute phase of dengue virus infections. NS1 tests can be as sensitive as molecular tests during the first 0-7 days of symptoms. After day 7, NS1 tests are not recommended.

Is NS1 antigen specific for dengue?