Is Conotoxin a select agent?
Is Conotoxin a select agent?
The short, paralytic alpha conotoxins containing the following amino acid sequence X1 CCX2 PACGX3 X4 X5 X 6 CX 7 will be considered a select toxin if the total amount (all forms) under the control of a principal investigator, treating physician or veterinarian, or commercial manufacturer or distributor exceeds 100 mg …
What is a CDC select agent?
Select agents are biological agents and toxins that have been determined to have the potential to pose a severe threat to public health and safety, to animal and plant health, or to animal or plant products.
What are NIH select agents?
A select agent is a biological agent or toxin that has the potential to pose a severe threat to public health and safety, animal or plant health, or animal or plant product.
What is a Tier 1 select agent?
A subset (Tier 1) of select agents and toxins have been identified as presenting the greatest risk of deliberate misuse with most significant potential for mass casualties or devastating effects to the economy, critical infrastructure, or public confidence.
What is Conotoxin made from?
A conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail, genus Conus. Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have one or more disulfide bonds.
What is a Tier 1 select agent or toxin?
Tier 1 Select agents and toxins – A subset of select agents and toxins have been designated as Tier 1 because these biological agents and toxins present the greatest risk of deliberate misuse with significant potential for mass casualties or devastating effect to the economy, critical infrastructure, or public …
Is H7N9 a select agent?
Select Agent Status and Permitting Requirements Based on the known sequence data and epidemiology, this influenza A(H7N9) virus will be handled as a LPAI and not subject to USDA select agent requirements.
What is a category A select agent?
These category A select agents are variola major virus (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularemia), and the viral hemorrhagic fever agents Arenaviridae (Lassa fever, Junin-Argentine hemorrhagic fever, and Venezuelan …
Is Brucella a select agent?
Both Brucella species are listed as overlap select agents under the select agent and toxin regulations. 9 C.F.R. § 121.4(b), 42 C.F.R. § 73.4(b).
Is Burkholderia pseudomallei a select agent?
Burkholderia pseudomallei is a Tier 1 select agent and potential bioweapon. pseudomallei strains at BSL-2, or research with surrogate species, such as Burkholderia thailandensis.
What is Conotoxin used for?
Conotoxins are bioactive peptides found in the venom that marine cone snails produce for prey capture and defense. They are used as pharmacological tools to study pain signalling and have the potential to become a new class of analgesics.
How does Conotoxin cause paralysis?
Conotoxins, found in sea cone snails, are used by these organisms for predatory purposes: they paralyze their prey by blocking or inhibiting various targets of the nervous system.
What does the division of select agents and toxins mean?
Division of Select Agents and Toxins: What is a Select Agent? Select agents are biological agents and toxins that have been determined to have the potential to pose a severe threat to public health and safety, to animal and plant health, or to animal or plant products. regulated by the Federal Select Agent program.
Who are the members of the Federal select agent program?
Overview. The Federal Select Agent Program is jointly comprised of the Centers for Disease Control and Prevention/Division of Select Agents and Toxins and the Animal and Plant Health Inspection Service/Agriculture Select Agent Services.
How many select agents are there in the world?
DSAT – What is a Select Agent? | CDC Division of Select Agents and Toxins: What is a Select Agent? Select agents are biological agents and toxins that have been determined to have the potential to pose a severe threat to public health and safety, to animal and plant health, or to animal or plant products. There are 67 select agents and toxins
How to report an issue with a select agent?
To report safety, security, or other concerns associated with select agents and toxins, please use the Office of Inspector General (OIG)’s confidential hotline. When reporting these issues to OIG, please ensure that you indicate it is a “Select Agent Complaint” issue.
