Where are GLUT2 transporters found?
Where are GLUT2 transporters found?
liver
GLUT2 is the major transporter isoform expressed in adult liver, pancreatic beta cells, and epithelial cells of the intestinal mucosa and kidney.
Where is glut located?
58.4 The GLUT Gene Family GLUT3 protein is located mainly in the brain where it is responsible for glucose uptake into neurons, and GLUT4 is the major glucose transporter in adipocytes and skeletal and cardiac muscle.
What glucose transporter is found in the liver?
Glycogen Storage Diseases Glucose transporter type 2 (GLUT2) predominates in the liver (and pancreatic beta cells) and has a high Km (≈15 to 20 mmol/L); consequently, the free glucose concentration in hepatocytes increases in direct proportion to the increase in plasma glucose concentration.
Where are glucose transporters located?
the plasma membrane
Glucose transporters are found in the plasma membrane where they bind to glucose and enable its transport across the lipid bilayer. They can be divided into two classes: the sodium-glucose cotransporters or symporters (SGLTs) and the facilitative glucose transporters (GLUTs).
What type of transporter is GLUT2?
GLUT2 is the major glucose transporter inβ -cells of pancreatic islets and hepatocytes. In both cell types, GLUT2 mediates the facilitated diffusion of glucose across the cell membranes, and then intracellular glucose metabolism is initiated by the glucose-phosphorylating enzyme, hexokinase IV or glucokinase.
Is GLUT2 an active transporter?
Once inside the epithelial cells, glucose reenters the bloodstream through facilitated diffusion through GLUT2 transporters. As the cotransport of glucose with sodium from the lumen does not directly require ATP hydrolysis but depends upon the action of the ATPase, this is described as secondary active transport.
What is the function of GLUT 2?
What is the difference between GLUT 2 and GLUT4?
All GLUT proteins allow movement into, GLUT 2 is the one that allows both into and out of. GLUT 4 requires insulin. GLUT4 is on muscle cells and adipocytes. GLUT 1, 2 and 3 do not require insulin.
Is GLUT4 in the liver?
The last-mentioned glucose transporter GLUT4 is known as major isoform in muscular and adipose tissues and only shows minor expression levels in the liver as well [228].
What are glucose transport channels?
Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose across the plasma membrane, a process known as facilitated diffusion. Because glucose is a vital source of energy for all life, these transporters are present in all phyla. 14 GLUTS are encoded by human genome.
What type of protein is GLUT2?
Glucose transporter
Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes.
What is GLUT2 used for?
What kind of transporter does GLUT2 have?
GLUT2 is a low-affinity (for glucose) transporter with a high capacity able to move large amounts of glucose in two directions in or out of the cell.
What is the function of glucose transporter 2?
Glucose transporter 2 ( GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 ( SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes. It is the principal transporter for transfer of glucose between liver and blood,…
Where are GLUT2 isoforms found in the body?
GLUT2 is the major glucose transporter isoform expressed in hepatocytes, insulin-secreting pancreatic beta cells, and absorptive epithelial cells of the intestinal mucosa and kidney.
What are the effects of mutations in GLUT2?
Mutations of GLUT2 (the gene for the glucose transporter protein 2) can result in hypoglycemia, hepatorenal glycogen accumulation, and a combination of features described as the Fanconi-Bickel syndrome. GLUT2 is a monosaccharide transporter occurring in the plasma membranes of beta cells, renal tubule cells, and hepatocytes, among other tissues.
