What is the active metabolite of the drug procainamide?
What is the active metabolite of the drug procainamide?
Procainamide is both metabolized and excreted renally, and its active metabolite, N-acetyl procainamide (NAPA), is cleared primarily by renal excretion.
For which of the following is administration of procainamide indicated?
Indications and Usage Procainamide hydrochloride injection is indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgement of the physician, are life-threatening.
What is the most common adverse effect of procainamide?
Common side effects of Pronestyl (procainamide hydrochloride) include nausea, vomiting, loss of appetite, diarrhea, bitter taste in the mouth, dizziness, tired feeling, flushing (warmth, redness, or tingly feeling), and itching or rash.
What is the purpose of procainamide?
Procainamide is used to treat abnormal heart rhythms. It works by making your heart more resistant to abnormal activity.
What is procainamide indicated for?
How is procainamide supplied?
PRONESTYL (procainamide hydrochloride) is supplied for oral administration as capsules and tablets in potencies of 250, 375, and 500 mg.
How do you monitor procainamide?
How should I monitor my patient? A. Initiate procainamide while your patient is hospitalized and monitor cardiac rate and rhythm, including QTc interval; BP; and monitor for hypersensitivity reactions. Also monitor his complete blood cell count, ANA titer, and kidney and liver function for blood abnormalities.
What is a milrinone drip used for?
Milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Milrinone is used as a short-term treatment for life-threatening heart failure.
How much procainamide should I take for ACLS?
Adult Dosage for Procainamide: The use of procainamide is limited in ACLS for cardiac arrest, due to its requirement of slow infusion and its somewhat unknown effectiveness. If used for recurrent ventricular fibrillation and pulseless ventricular tachycardia, 20 mg/min should be given via IV infusion to a total dose of 17 mg/kg.
Which is the most active metabolite of procainamide?
The major active metabolite, NAPA, has antiarrhythmic properties. Other urinary metabolites include desethyl-NAPA and desethyl-procainamide, which account for 8 to 15% of a dose of procainamide. The exact relationship between antiarrhythmic activity and plasma levels of NAPA has not been established.
What is the half life of procainamide in children?
Congestive heart failure increases the plasma procainamide half life to 5 to 8 hours. The half-life is reduced in children and is prolonged in patients with renal insufficiency. Its major active metabolite, N-acetylprocainamide (NAPA), has a longer half-life than procainamide, from 6 hours up to 36 hours in overdoses.
What is the dosage of procainamide for atrial fibrillation?
Adult Dosage for Procainamide: For supraventricular tachycardia, atrial fibrillation, and wide complex tachycardias of uncertain origin, procainamide should be administered at 20 mg/min via IV infusion to a total of 17 mg/kg. For maintenance, it can be administered at 1 to 4 mg/min titrated to desired effect and patient’s response.
