What is TAF MEK?
What is TAF MEK?
TAFINLAR and MEKINIST are prescription medicines that can be used in combination to treat a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic NSCLC), and that has a certain type of abnormal “BRAF V600E” gene. Learn more. APPROVED USES.
How long does Tafinlar and Mekinist work?
Of the 22 untreated patients who had a response with TAFINLAR + MEKINIST, 59% had a duration of response of 6 months or longer before their disease got worse. The median (or midpoint) duration of response for patients who were previously treated was 12.6 months.
What type of drug is Tafinlar?
Enzyme inhibitor
Dabrafenib/Classification
What are the side effects of Tafinlar?
Common side effects of TAFINLAR and MEKINIST in people with NSCLC include:
- Fever.
- Fatigue.
- Nausea.
- Vomiting.
- Diarrhea.
- Dry skin.
- Decreased appetite.
- Rash.
How do MEK inhibitors work?
MEK inhibitors bind to and inhibit MEK, inhibiting MEK-dependent cell signaling. This inhibition leads to cell death and the inhibition of tumor growth. These are allosteric binding inhibitors of MEK which inhibit either MEK1 alone, or both MEK1 and MEK2.
What is the cost of the drug Mekinist?
This is a brand name drug and a generic may be available. The average cost for 1 Bottle, 30 tablets each, is $14,335.79. You can buy Mekinist at the discounted price of $12,749.40 by using the WebMDRx coupon, a savings of 11%. Even if this drug is covered by Medicare or your insurance, we recommend you compare prices.
How long can you take Mekinist?
Recommended Dosage For The Adjuvant Treatment Of Melanoma The recommended dosage of MEKINIST is 2 mg orally taken once daily in combination with dabrafenib until disease recurrence or unacceptable toxicity for up to 1 year. Refer to the dabrafenib prescribing information for recommended dabrafenib dosing information.
Can you open Tafinlar?
Swallow Tafinlar capsules whole. Do not crush, open or dissolve capsules. Do not change your dose or stop Tafinlar unless your health care provider tells you to.
Where is melanoma found in the body?
Melanomas can develop anywhere on the skin, but they are more likely to start on the trunk (chest and back) in men and on the legs in women. The neck and face are other common sites.
Is it best to take Tafinlar before or after meal?
It is important to take TAFINLAR on an empty stomach. Food may affect the way the medicine is taken up (absorbed) into your body. If taking TAFINLAR AFTER eating a meal or having a drink, wait at least two (2) hours before taking TAFINLAR. Swallow each capsules whole, with a full glass of water.
What are MEK inhibitor drugs?
A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2. They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers.
