What is SOX9 a marker for?

What is SOX9 a marker for?

SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma.

Where is SOX9 gene located?

SOX9 sits in a gene desert on 17q24 in humans. Deletions, disruptions by translocation breakpoints and a single point mutation of highly conserved non-coding elements located > 1 Mb from the transcription unit on either side of SOX9 have been associated with Pierre Robin Sequence, often with a cleft palate.

Is SOX9 a transcription factor?

The SOX9 protein attaches (binds) to specific regions of DNA and regulates the activity of other genes, particularly those that control skeletal development and sex determination. On the basis of this action, the SOX9 protein is called a transcription factor.

What does Sox9 stand for?

The protein SRY (sex determining region Y)-box 9 (Sox9) is a transcription factor expressed in some solid tumors, including HCC. However, the molecular mechanisms underlying Sox9 function in liver CSCs remain unclear.

What is Sox9 enabled?

SOX9 (locus: 17q24. 3) encodes a transcription factor essential for normal testicular differentiation as well as the development of the skeleton and other organs. It plays several roles in the sex-determining pathway, namely, to activate AMH, FGF9, and PTGDS and to maintain its own expression.

What chromosome is Sox9 on?

Campomelic dysplasia (CD) is a skeletal malformation syndrome frequently accompanied by 46,XY sex reversal. A mutation-screening strategy using SSCP was employed to identify mutations in SOX9, the chromosome 17q24 gene responsible for CD and autosomal sex reversal in man.

Do females have Sox9?

Subsequently, consistent with a role in testis determination, Sox9 is upregulated by Sry92 in male genital ridges, where it becomes localized to the nuclear compartment, and is downregulated in females.

Why do we need astrocytes?

The broad role of astrocytes is to maintain brain homeostasis and neuronal metabolism. It’s hypothesized that the “star-shape” supports the neurons and creates the microarchitecture of the brain parenchyma illustrating that form-follows-function rule seen across biology.

Which chromosome is Sox9 on?

Does SRY activate Sox9?

Hence, SRY determines Sertoli cell fate by repressing ovarian and activating testicular differentiation genes, promotes early Sertoli cells to form testis cord, and then passes on its functions to SOX9, which regulates common targets and activates its own gene regulatory program, beyond SRY actions, in sex …