What are hormones analogues?

The GnRH analogues are potent therapeutic agents that are considerably useful in a variety of clinical indications. These indications include management of endometriosis, uterine leiomyomas, hirsutism, dysfunctional uterine bleeding, premenstrual syndrome, assisted reproduction, and some hormone-dependent tumors.

What are luteinizing hormone-releasing hormone agonist?

A substance that keeps the testicles and ovaries from making sex hormones by blocking other hormones that are needed to make them. In men, luteinizing hormone-releasing hormone agonists cause the testicles to stop making testosterone.

Are LHRH and GnRH the same?

Gonadotropin-releasing hormone causes the pituitary gland in the brain to make and secrete the hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Also called GnRH, LH-RH, LHRH, and luteinizing hormone-releasing hormone.

What is the key difference between LHRH agonist and LHRH antagonist therapies?

LHRH antagonists bind to the LHRH receptors on pituitary gonadotropin-producing cells. They do not cause an initial release of luteinizing hormone or follicle-stimulating hormone, and thus avoiding the flare phenomenon of LHRH agonists.

How does gonadotropin releasing hormone analogs work?

Gonadotropin releasing hormone agonists (GnRH) are a type of medication that suppresses ovulation by stopping the production of estrogen and progesterone. In order for this axis to function properly and result in ovulation, GnRH has to be released in a pulsatile fashion.

What does luteinizing hormone do?

LH is made by your pituitary gland, a small gland located underneath the brain. LH plays an important role in sexual development and functioning. In women, LH helps control the menstrual cycle. It also triggers the release of an egg from the ovary.

How do GnRH analogues work?

What releases releasing hormone release?

Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland.

What inhibits LHRH release?

These results indicate that both testosterone and dihydrotestosterone inhibit LHRH-induced LH release and that this activity of testosterone does not depend on its 5 alpha-reduction.

How are luteinizing hormone ( LHRH ) agonists work?

LHRH agonists are synthetic analogs of the normal human hormone luteinizing hormone-releasing hormone, which is produced in the human hypothalamus and stimulates the production of a second hormone known as luteinizing hormone(LH). It is luteinizing hormone which, under normal circumstances, stimulates the production of testosterone in men.

How are LHRH agonists used in prostate cancer treatment?

LHRH agonists are used in the following ways in the management of metastatic prostate cancer: On their own for the long-term, continuous suppression of the male hormone testosterone In combination with other drugs (such as nonsteroidal antiandrogens) for continous suppression of testosterone and other male hormones

Which is the hormone that stimulates the production of testosterone?

It is luteinizing hormone which, under normal circumstances, stimulates the production of testosterone in men. All LHRH agonists are small synthetic proteins and are structurally similar to normal human LHRH.

How is gonadotropin releasing hormone ( GnRH ) controlled?

GnRH controls the secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. Secretion of GnRH is controlled by neural input from other parts of the brain and in females particularly, through negative feedback by the sex steroids.