Which antiemetic does not cause QT prolongation?

Which antiemetic does not cause QT prolongation?

Both ondansetron and granisetron prolong the QT interval when administered intravenously at doses over 8 mg and 10 micrograms/kg respectively. However, there have been no reports of QT prolongation following oral administration. Palonosetron and tropisetron are not associated with QT prolongation.

Does metoclopramide prolong QT interval?

Explanation. While the exact mechanism for this adverse drug effect is not fully known, it is thought that metoclopramide has pharmacologic characteristics that can contribute to the prolongation of the QT interval and risk for polymorphic ventricular tachycardia.

Can you give Zofran with prolonged QTc?

ECG changes including QT interval prolongation have been observed in patients receiving ondansetron. In addition, Torsade de Pointes, an abnormal, potentially fatal, heart rhythm, has been reported in some patients receiving ondansetron. The use of a single 32 mg intravenous dose of ondansetron should be avoided.

Does Cyclizine cause QT prolongation?

Cyclizine would be the anti-emetic of choice in this patient as it has not been associated with QT prolongation.

Does Decadron prolong QT?

Treatment with high-dose dexamethasone was repeatedly associated with a decrease in the QT interval that was reversible upon cessation of treatment.

Does Thorazine cause QT prolongation?

Chlorpromazine is considered a high-risk drug for QTc prolongation, with one study finding an increased relative risk of 1.37 (95% CI 1.14-1.64).

Is amiodarone contraindicated in torsades?

Do not use amiodarone, procainamide, beta-blockers, or most other antiarrhythmics. Most of these will stretch out the QT interval even further! Beta-blockers will slow down the heart rate, increasing the risk of torsades.

Do beta blockers prolong QT?

Beta-blockers have heart-rate-dependent effects on the QT and QTc intervals in LQTS. They appear to increase the QT and QTc intervals at slower heart rates and shorten them at faster heart rates during exercise.

Does Keppra prolong QTc?

Levetiracetam did not significantly prolong the QTc(ss).

Does amiodarone prolong QT?

Amiodarone is an antiarrhythmic agent known to cause prolongation of action potential duration which is reflected in the electrocardiogram as a prolongation of the QT interval.

Does Seroquel prolong QTc?

Quetiapine, an atypical antipsychotic used in the intensive care unit (ICU) to manage delirium, has a possible adverse effect of corrected QT (QTc) interval prolongation.

Does Compazine prolong QTc?

Prochlorperazine (Compazine®) is generally safe to give when the QTc interval for men is less than 450 milliseconds per beat, and for women, less than 460 milliseconds per beat. The QTc interval is prolonged if the heart takes too long to make the next beat, and could lead to a dangerous heartbeat known as an arrhythmia.

Does Phenergan prolong QT interval?

Phenergan and Electrocardiogram qt corrected interval prolonged – from FDA reports. Electrocardiogram qt corrected interval prolonged is found among people who take Phenergan, especially for people who are male, 60+ old also take medication Ativan, and have Abdominal pain upper.

Does Reglan prolong QT interval?

Reglan (metoclopramide) does lead to prolonged QT interval which increased the risk of heart arrhythmias and Torsades de Pointes . The consequence of the drug has been linked to the pharmacological traits of the drug which creates an environment where it can cause prolongation of the QT interval.