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What is thermodynamic product?

What is thermodynamic product?

The thermodynamic product is the most stable product with the lowest energy (the relative stability of the products) The distinction is relevant when product A forms faster than product B because the activation energy for product A is lower than that for product B, yet product B is more stable.

What is kinetic vs thermodynamic product?

A simple definition is that the kinetic product is the product that is formed faster, and the thermodynamic product is the product that is more stable. There are plenty of reactions in which the more stable product (thermodynamic) is also formed faster (kinetic).

Does LDA form the kinetic or thermodynamic product?

Thus a strong, hindered base like LDA, at low temperatures, typically will favour formation of the kinetic enolate. However, if the pKa difference between the base and the enolate is not great, then enolate formation is reversible.

What is kinetically stable product?

Kinetic stability, in the context discussed here, is a measure of how rapidly a protein unfolds. In such a case, the structure will, to all intents and purposes, be trapped in a local minimum, and that locally minimized structure will be the folded state for that protein. …

What does it mean to be kinetically favored?

E.g. given reactants often produce more than one product. One product might be more stable than another, i.e. thermodynamically favoured, but the path to another might in given conditions be faster so that is what you could get more of and you would call that being kinetically favoured.

What are thermodynamic factors?

The thermodynamic factor in diffusion is a parameter relating the tracer diffusion coefficient of a species in a given system to the corresponding intrinisc diffusion coefficient[lJ] and may be defined for alloys[l-31 as well as for oxides both pure and mixed[3-91.

Is the Hofmann product the kinetic or thermodynamic product?

The Zaitsev product is also known as the thermodynamic product, since it is the one that releases the most free energy overall (most negative ΔG°). The Hofmann product is also known as the kinetic product, since it is the one that overcomes the lowest activation energy (Ea).

Why is thermodynamic product more stable?

Thermodynamic products contain an internal double bond and the reaction is reversible. Also, when reactions are carried out, thermodynamic products are more stable than kinetic products because they are more substituted.

What is meant by thermodynamic stability?

Thermodynamic stability occurs when a system is in its lowest energy state, or in chemical equilibrium with its environment. This type of chemical thermodynamic equilibrium will persist indefinitely unless the system is changed.

What is thermodynamic and kinetic enolate?

Treatment of an unsymmetrical ketone with a base could result in two enolate ions. The more stable enolate ion is called the thermodynamic enolate and the faster forming one the kinetic enolate.

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Ruth Doyle