What is pure red cell aplasia PRCA?
What is pure red cell aplasia PRCA?
Pure red cell aplasia (PRCA) is a rare disorder of blood production in which the bone marrow, the spongy tissue in the center of the bones, fails to function in an adequate manner resulting in anemia. Red blood cells are responsible for carrying oxygen to the entire body.
How is PRCA treated?
The most effective first-line treatment of idiopathic PRCA is cyclosporine A (CsA) administered at a starting dose of 2 to 6 mg/kg per day (in divided doses) possibly combined with steroid (prednisone at 30 mg/day) with a rapid taper, yielding an overall response rate (ORR) of about 65% to 87%.
What is acquired pure red cell aplasia?
INTRODUCTION. Acquired pure red cell aplasia (PRCA) is a rare cause of profound anemia characterized by a very low reticulocyte count and the virtual absence of erythroid precursors in the bone marrow. All other cell lineages are present in normal numbers and appear morphologically normal.
What is red cell aplasia caused by?
Causes. Acquired Pure Red Cell Aplasia is thought to be an autoimmune disorder possibly caused either by a tumor of the thymus gland, certain drugs or a viral infection. It is one of a group of bone marrow failure syndromes.
What is EPO used for?
Erythropoietin (EPO) is produced by the kidney and used to make red blood cells. Erythropoetin-stimulating agents are used often for people with long-term kidney disease and anemia.
What is stem cell aplasia?
Pure red cell aplasia (PRCA) is a potential complication after allogeneic stem cell transplantation (allo-SCT), which results from AB0 blood-group incompatibility causing persistent recipient antibodies directed against donor red cells and occurs in 6–30% depending on the conditioning regimen.
How is PRCA diagnosed?
The diagnosis of PRCA is based on the absence or near absence of erythroblasts from an otherwise normal marrow (<1% erythroblasts on the marrow differential count). In some cases, a few proerythroblasts and/or basophilic erythroblasts are seen, not exceeding 5% of the differential count.
What is bone marrow aplasia?
Bone marrow aplasia is a disease in which the red bone marrow disappears and consequently ceases to produce red blood cells, white blood cells and platelets. Bone marrow aplasias can be distinguished between congenital, the most frequent, and acquired aplasias.
What produces hemoglobin?
Your body uses iron to make hemoglobin. A lack of iron in the body is the most common cause of anemia.
Where can I find information about the PRCA?
ProRodeo.com. The PRCA maintains a website with the latest news stories, cowboy blogs, world standings, rodeo results, cowboy and livestock bios, and tons of other information. The PRCA also has a Facebook presence. Read more on page 7.
How many rodeos are sanctioned by the PRCA?
The recognized leader in ProRodeo, the PRCA is committed to maintaining the highest standards. The PRCA, a membership-based organization, sanctions approximately 600 rodeos annually, and there are more than 30 million fans in the U.S. Competition.
What does the PRCA stand for in Christianity?
The PRCA stand in the line of historic Christianity, believing and confessing the basic truths of the infallibly inspired Word of God. This is “the faith… once delivered unto the saints” ( Jude 3 ), the “traditions” handed down to us by Jesus Christ through His apostles and prophets ( Eph.2:20 ; 2 Thess.2:15 ).
Who are the official charities of the PRCA?
Charities. PRCA-sanctioned rodeos annually raise many millions of dollars for local and national charities, from college scholarships for local students to the national Tough Enough to Wear Pink campaign against breast cancer. FanZone. The ProRodeo FanZone is the official fan club of the PRCA.
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