What is diisopropylamine dichloroacetate?
What is diisopropylamine dichloroacetate?
Diisopropylamine dichloroacetate (DADA) is the active component of pangamic acid and has been commercially available for over 50 years for the treatment of chronic liver disease [19]. It has been previously reported that DADA is a safe inhibitor of pyruvate dehydrogenase kinase 4 (PDK4), which is a PDK subtype [20].
What does Dichloroacetate do to your body?
Oral dichloroacetate sodium (DCA) has been investigated as a novel metabolic therapy for various cancers since 2007, based on data from Bonnet et al that DCA can trigger apoptosis of human lung, breast and brain cancer cells.
What is sodium dichloroacetate used for?
Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological property of inhibiting pyruvate dehydrogenase kinase.
What is DCA treatment for cancer?
Dichloroacetate, or DCA, is a synthetic chemical used for cosmetic and clinical purposes. It’s commercially available as a cauterizing agent, meaning it burns the skin. This drug became popular in 2007 after a Canadian study suggested DCA might be able to reverse cancer growth.
What is DCA made of?
Dicholoroacetates are salts of dichloroacetic acid. Both the salt and acid are man-made chemicals. DCA is a by-product of the chlorine disinfection of water. 1 2 DCA is a powder that can be made into pill form.
What is antineoplastic material?
Antineoplastic drugs are medications used to treat cancer. Antineoplastic drugs are also called anticancer, chemotherapy, chemo, cytotoxic, or hazardous drugs. These drugs come in many forms. Some are liquids that are injected into the patient and some are pills that patients take.
Is dichloroacetic acid a strong acid?
As an acid with a pKa of 1.35, pure dichloroacetic acid is classed as a strong organic acid; it is very corrosive and extremely destructive to tissues of the mucous membranes and upper respiratory tract via inhalation.
What DCA means?
Dollar-cost averaging
Dollar-cost averaging (DCA) is the automatic investment of a set monetary amount on a periodic basis.
Is antineoplastic a drug class?
The antineoplastic agents or anticancer drugs represent a large and diverse class of medications. They generally have limited but important uses, and often have significant hepatotoxicity.
Why is Warburg effect bad?
Contemporary explanation of the Warburg effect In addition to being energetically highly inefficient process glycolysis (either anaerobic or aerobic), with its metabolic products (such as hydrogen ions), cause constant acidification of the extracellular space, which might result in increased local toxicity [[9], [10]].
