What are Leukoreduced platelets?
What are Leukoreduced platelets?
This is the formal name for a unit of whole blood derived platelets (known to some as “platelet concentrate” or “random platelets”) that has had the vast majority of its white blood cells removed (see the entry on leukocyte reduction for more information on why we would do so).
Why is Leukoreduction important?
Leukoreduction: A process used to filter and remove white blood cells from whole blood before transfusion. The reason why white blood cells (leukocytes) are removed from blood is because they provide no benefit to the recipient but can carry bacteria and viruses to the recipient.
What is refractory to platelets?
Definitions. Platelet refractoriness: A patient is refractory to platelet transfusions if the patient’s circulating platelet levels consistently fail to increase by at least 10k/µliter after transfusion of an appropriate dose of platelets.
How low do platelets have to be for transfusion?
There is reasonable consensus that for patients who are bleeding, septic, or hemodynamically unstable, the threshold for transfusion should be raised to 15,000-20,000/µL. Patients with life-threatening bleeding in the chest or head are usually transfused at higher platelet count thresholds (30,000-50,000/µL).
When is leukoreduction performed?
Leukoreduction can be performed before the component is stored (prestorage leukoreduction) or at the time blood is issued for transfusion (poststorage leukoreduction).
What is leukoreduction filtration?
Abstract. Leukoreduction of blood products is a technique used to prevent leukocyte-induced transfusion reactions. Filters currently used for human blood products achieve at least a 99.9% reduction in leukocyte numbers per unit (450 mL) of blood.
How is leukoreduction performed?
Leukoreduction can be performed by filtration prior to component storage (prestorage leukoreduction) or during the transfusion (bedside filtration). For apheresis-derived platelets, leukoreduction is often performed by cell separation during the apheresis collection.
What is leukoreduction filter?
Leukoreduction of blood products is a technique used to prevent leukocyte-induced transfusion reactions. Filters currently used for human blood products achieve at least a 99.9% reduction in leukocyte numbers per unit (450 mL) of blood.
When do you check platelets after platelet transfusion?
A single unit of platelets is the standard for transfusion, with the exception of patients on Plavix with bleeding. After giving 1 unit, check the platelet count 15 minutes-1 hour after transfusion, and re-evaluate for on-going bleeding, if a second unit is needed to achieve the platelet goal.
How is leukoreduction used to treat platelets?
Leukoreduced Blood Products Leukoreduction techniques can be used for RBC and platelet units. The units are filtered before storage or at the bedside. Current third‐generation leukocyte filters are capable of removing more than 99.99% (4‐log reduction) of leukocytes with less than 10% RBC loss.
What does it mean when your platelets are low?
Platelets are blood cells called thrombocytes and help your blood clot, so you stop bleeding. Low platelet count is also called thrombocytopenia.
What should your platelet count be to donate blood?
Platelets, also known as thrombocytes, are the part of your blood that helps it clot and stop bleeding. A normal platelet count ranges from 150,000 to 400,000 per microliter of blood. A count lower than 150,000 is considered thrombocytopenia and may affect your ability to donate platelets, among other things.
Which is more effective pre or post leukoreduction?
Both pre- and poststorage leukoreduction, are effective in preventing antibody-mediated reactions to RBCs and platelets. Poststorage leukoreduction is not effective in preventing reactions to platelets that are mediated by accumulation of cytokines released from leukocytes during storage.
