What is the difference between pegfilgrastim and Lipegfilgrastim?

Lipegfilgrastim has a lower risk of febrile neutropenia versus filgrastim but was also not statistically significant. The risk ratio for severe neutropenia in cycle 1 was 0.80, a 20% reduction in favor of lipegfilgrastim. For cycles 2-4, the risk ratio was 0.53 (0.35, 0.79) for lipegfilgrastim versus pegfilgrastim.

What is the drug Zarxio used for?

ZARXIO is used to reduce the risk of infection in patients with some tumors who are receiving strong chemotherapy that may cause severe neutropenia with fever.

What is pegfilgrastim used for?

Pegfilgrastim injection products are used to reduce the chance of infection in people who have certain types of cancer and are receiving chemotherapy medications that may decrease the number of neutrophils (a type of blood cell needed to fight infection).

Is pegfilgrastim a chemo drug?

This is not a chemotherapy drug. This medication is usually given at least 24 hours after chemotherapy to stimulate the growth of new, healthy, white blood cells (WBC). Pegfilgrastim is a longer acting form of filgrastim and the manufacturer recommends that it should not be given within 14 days prior to chemotherapy.

Is Zarxio self administered?

ZARXIO may be administered by you, a caregiver, or a healthcare provider. ZARXIO injections can be given by a healthcare provider by subcutaneous (under the skin) injection or by intravenous (IV) injection. Your healthcare provider may decide that subcutaneous injections can be given at home by you or your caregiver.

When should I take zarzio?

The first dose of Zarzio should be administered not less than 24 hours following cytotoxic chemotherapy and within 24 hours of bone marrow or PBPC infusion. Once the neutrophil nadir has been passed, the daily dose of Zarzio should be titrated against the neutrophil response as follows.

What is pegfilgrastim made of?

Pegfilgrastim was made by linking a 20-kDa polyethylene glycol molecule to filgrastim, producing a long-acting cytokine requiring less frequent dosing than its parent drug.

How effective is pegfilgrastim?

Pegfilgrastim, which requires only a single dose per cycle of chemotherapy, is the most commonly used CSF agent in the US, with previous evaluations reporting that it accounted for > 90% of all CSF prophylaxis use in their study populations [12, 15, 20, 24, 28, 29].

How long does pegfilgrastim last?

The timing can vary. Clinical studies showed that clearing Neulasta from the body is affected by your body weight and the number of neutrophils (a type of white blood cell) present in your blood. In general, after one injection, Neulasta is completely eliminated from your system within 14 days.

Can ZARXIO be given IV?

ZARXIO injections can be given by a healthcare provider by subcutaneous (under the skin) injection or by intravenous (IV) injection. Your healthcare provider may decide that subcutaneous injections can be given at home by you or your caregiver.

How do you give G CSF injection?

Insert the needle into your skin in one quick motion at a 90-degree (straight up and down) angle (see Figure 3). Don’t put your thumb on the plunger yet. After the needle is inserted, let go of your skin. Use your thumb (whichever thumb is more comfortable) to slowly push the plunger all the way down.

What kind of Medicine is lipegfilgrastim used for?

Lipegfilgrastim is a medication used to reduce the duration of chemotherapy-induced neutropenia and incidence of febrile neutropenia in cytotoxic chemotherapy.

What was previously known as lipegfilgrastim or XM22?

Lipegfilgrastim, previously known as XM22, is a pegylated, recombinant granulocyte colony-stimulating factor (G-CSF) that was synthetized using a highly site-specific glycoPEGylation technology 2.

What’s the half life of pegfilgrastim in humans?

Pegfilgrastim treatment can be used to stimulate bone marrow to produce more neutrophils to fight infection in patients undergoing chemotherapy. Pegfilgrastim has a human half-life of 15 to 80 hours, much longer than the parent filgrastim (3–4 hours).

Who is the manufacturer of pegfilgrastim in India?

Amgen manufactures pegfilgrastim under the brand name Neulasta, which was mainly worked on by Martine Allard, while Roche manufactures it under the name Neulastim. In India it is also marketed by Abbott Healthcare under the brand name Imupeg.