Do bisphosphonates affect teeth?

As bisphosphonates have a mode of action that interferes with the bone resorption by osteoclasts, they can have side effects in dental treatment, including inhibited tooth movement, impaired bone healing, and induced osteonecrosis in the maxilla and the mandible.

What are contraindications to bisphosphonates?

Contraindications to bisphosphonates include: History of hypersensitivity to the bisphosphonate. Hypocalcemia. Chronic kidney disease with a glomerular filtration rate of less than 30 to 35 mL/min.

What are the two main adverse effects of bisphosphonates?

General side effects of bisphosphonates and denosumab

Fever and flu-like symptoms.
Low levels of calcium in your blood (hypocalcaemia)
Bone and joint pain.
Changes in bowel movements.
Tiredness and low energy levels.
Feeling sick.
Changes to your kidneys.
Irritation of the food pipe (oesophagus)

Why do bisphosphonates cause osteonecrosis of the jaw?

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is thought to be caused by trauma to dentoalveolar structures that have a limited capacity for bone healing due to the effects of bisphosphonate therapy.

Can you have dental work while taking Zometa?

It is important that you tell all of your doctors that you are receiving zoledronic acid injection, including your dentist. If you are having dental procedures while receiving this medicine, you may have an increased chance of having a severe problem with your jaw.

What are oral bisphosphonates?

Oral bisphosphonates are commonly prescribed to prevent or treat osteoporosis in postmenopausal women. Common brand names of medications in this class include Fosamax, Actonel, Boniva, and Reclast.

Who should not take bisphosphonates?

Don’t take bisphosphonates if you:

Are allergic to them.
Have disorders of the food pipe (esophagus), including tears, holes, narrowing, or difficulty swallowing.
Have severe kidney disease.
Can’t sit in an upright position for at least 30 minutes.
Have low levels of calcium in your bloodstream.

What is the primary limitation of oral bisphosphonate therapy?

Because bisphosphonates inhibit osteoclast activity, there has been some concern that prolonged bisphosphonate treatment leads to “frozen bone,” characterized by over-suppression of bone remodeling, an impaired ability to repair skeletal microfractures, and increased skeletal fragility.

Does Zometa affect your teeth?

A dental condition called jaw osteonecrosis has been reported in some patients being treated with Zometa or with other drugs in the same class as Zometa. You may need to have dental treatments completed before starting it.

What is the risk of osteonecrosis of the jaw with bisphosphonates?

Among cancer patients receiving high-dose intravenous bisphosphonates, osteonecrosis of the jaw is dependent on dose and duration of therapy,17–20 and has an estimated incidence of 1% to 12%.