Is 400 mg of amiodarone too much?
Is 400 mg of amiodarone too much?
The recommended maintenance dose of amiodarone is 200 mg/day. A possible toxic level of amiodarone may be 400 mg daily for more than two months, or a low dose for more than two years.
How much is too much amiodarone?
Amiodarone has several potentially fatal toxicities, the most important of which is pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis) that has resulted in clinically manifest disease at rates as high as 10 to 17% in some series of patients with ventricular arrhythmias given doses …
How much amiodarone can you take in a day?
Adults—At first, 800 to 1600 milligrams (mg) per day taken in divided doses. Your doctor may adjust your dose as needed and tolerated. Children—Use and dose must be determined by your doctor.
Does amiodarone lower BP?
In addition to being an antiarrhythmic medication, amiodarone also causes blood vessels to dilate (enlarge). This effect can result in a drop in blood pressure. Because of this effect, it also may be of benefit in patients with congestive heart failure.
Is 400 mg of amiodarone safe?
Amiodarone hydrochloride has several potentially fatal toxicities, the most important of which is pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis) that has resulted in clinically manifest disease at rates as high as 10% to 17% in some series of patients with ventricular arrhythmias …
What is the best time of day to take amiodarone?
You can take amiodarone either before or after meals. If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose).
Can amiodarone cause heart failure?
Amiodarone’s pharmacodynamics, with an exceedingly large distribution volume leading to accumulation in the myocardium, may also play a part. Bradyarrhythmias could ensue, leading to sudden cardiac death in advanced heart failure.
How long can I stay on amiodarone?
Never stop taking it without consulting your doctor. This medication must be taken regularly for one to three weeks before a response is seen and for several months before the full effect occurs. Due to the drug’s long half-life, it will remain in your body for up to two months.
What are the side effects of amiodarone 200 mg?
The most common side effects that can occur with amiodarone oral tablet include:
- nausea.
- vomiting.
- fatigue.
- tremor.
- lack of coordination.
- constipation.
- insomnia.
- headache.
When should you not take amiodarone?
talk to your doctor about the risks of taking this medication if you are 65 years of age or older. Older adults should not usually take amiodarone because it is not as safe or effective as other medication(s) that can be used to treat the same condition.
How is the daily dose of Cordarone determined?
Cordarone may be administered as a single daily dose, or in patients with severe gastrointestinal intolerance, as a b.i.d. dose. In each patient, the chronic maintenance dose should be determined according to antiarrhythmic effect as assessed by symptoms, Holter recordings, and/or programmed electrical stimulation and by patient tolerance.
Are there any side effects to taking Cordarone IV?
The most common side effects of Cordarone IV include: Tell the doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Cordarone. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.
What is the half life of Cordarone for amiodarone?
Following single dose administration in 12 healthy subjects, Cordarone exhibited multi-compartmental pharmacokinetics with a mean apparent plasma terminal elimination half-life of 58 days (range 15 to 142 days) for amiodarone and 36 days (range 14 to 75 days) for the active metabolite (DEA).
When to reduce Cordarone dose to control arrhythmia?
When adequate arrhythmia control is achieved, or if side effects become prominent, Cordarone dose should be reduced to 600 to 800 mg/day for one month and then to the maintenance dose, usually 400 mg/day (see “CLINICAL PHARMACOLOGY–Monitoring Effectiveness”).
