What is the drug DEFINITY used for?
What is the drug DEFINITY used for?
DEFINITY® is an injectable cardiovascular ultrasound enhancement agent comprised of lipid-coated echogenic microbubbles filled with octafluoropropane gas. Administration of DEFINITY® enhances clinicians’ view of the left ventricle of the heart during an echocardiogram to aid with diagnosis.
What type of contrast is DEFINITY?
A Trusted Agent With a Proven Safety Profile and Extensive Experience. DEFINITY® is the #1 prescribed ultrasound enhancing agent in the United States. DEFINITY® is a diagnostic ultrasound enhancing agent used in patients with suboptimal echocardiograms.
Why is DEFINITY used in Echo?
Activated DEFINITY® is indicated for use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border. Suboptimal echocardiography is defined as the inability to visualize at least 2 left ventricular segments.
What is perflutren lipid microsphere used for?
Perflutren lipid microsphere injection is used during an echocardiogram to help diagnose or find problems in the heart. Perflutren lipid microsphere is an ultrasound contrast agent. Ultrasound contrast agents are used to help provide a clear picture during ultrasound.
Is DEFINITY safe?
DEFINITY® is the first and only approved ultrasound enhancing agent in the United States that offers flexible dosing and is approved for use in diluted form. With its proven safety profile, DEFINITY® is the most used, most studied, most trusted ultrasound enhancing agent with exposure in more than 13 million patients.
Is DEFINITY contrast safe in pregnancy?
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. It is not known whether DEFINITY® is excreted in human milk.
Does DEFINITY affect the kidneys?
Definity® has been approved in the United States for cardiac indications. Extensive studies of these agents have demonstrated a significant safety profile with no evidence of toxicity to the kidneys, heart or liver.
Is DEFINITY a drug?
Definity is an ultrasound contrast agent that is used to improve the quality of an echocardiogram (ultrasound of the heart). This medicine works by changing the way ultrasound waves travel within your heart.
Is Definity a drug?
Is Definity iodine based?
What Is DEFINITY® Made of? Activated DEFINITY® is comprised of a synthetic formulation of microbubbles composed of octafluoropropane gas encapsulated by a synthetic phospholipid shell. DEFINITY® does not contain iodine, radioactive materials, or gadolinium.
Is DEFINITY radioactive?
Activated DEFINITY® is comprised of a synthetic formulation of microbubbles composed of octafluoropropane gas encapsulated by a synthetic phospholipid shell. DEFINITY® does not contain iodine, radioactive materials, or gadolinium.
How long does Definity stay in your body?
The activated Definity may be used for up to 12 hours from the time of activation, but only after the microspheres are resuspended by hand agitation.
When to use perflutren lipid microsphere activated Definity?
Activated Definity ® (Perflutren Lipid Microsphere) Injectable Suspension is indicated for use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border. Definity Dosage and Administration
How much octafluoropropane is in Definity 2 mL?
DEFINITY is supplied as a single use 2-mL clear glass vial containing a clear liquid in packages of four (4) and sixteen (16) single-use vials. Prior to activation, the headspace of each vial contains 6.52 mg/mL octafluoropropane and the clear liquid contains 0.75mg/mL of a lipid blend.
How to store activated Definity at room temperature?
Store the activated Definity® at room temperature in the original product vial. Invert the vial and withdraw the activated milky white suspension using the Intellipin™ (Dispensing Pin) or 18 to 20 gauge syringe needle. Withdraw the material from the middle of the liquid in the inverted vial. Do not inject air into the Definity® VIAL.
What happens if Definity is not properly activated?
Definity will not be properly activated unless the full 45 second activation cycle is completed. Error messages will display if the vial is not properly activated. Do not reactivate the vial if Vialmix or Vialmix RFID did not properly activate the vial. Never reactivate a successfully activated Definity vial (see step 3).
