What is the pathophysiology of drug-induced hepatitis?
What is the pathophysiology of drug-induced hepatitis?
The pathogenesis of drug-induced liver injury usually involves the participation of a toxic drug or metabolite that either elicits an immune response or directly affects the biochemistry of the cell. In either case, the resultant cell death is the event that leads to the clinical manifestation of hepatitis [2, 6].
What is drug-induced hepatitis?
Drug-induced hepatitis is a redness and swelling (inflammation) of the liver that is caused by a harmful (toxic) amount of certain medicines. The liver helps to break down certain medicines in your blood. If there is too much medicine in your blood for your liver to break down, your liver can become badly damaged.
What is drug-induced liver disease?
Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes.
What is the most common cause of drug-induced liver injury?
Large doses of many medicines can damage a normal liver. Many different drugs can cause drug-induced hepatitis. Painkillers and fever reducers that contain acetaminophen are a common cause of liver injury, particularly when taken in doses greater than those recommended.
What is drug induced?
A drug-induced state or reaction is provoked by a drug. Narcotic overdoses cause a number of drug-induced deaths. Psychosis brought on by drug use is called drug-induced psychosis. A drug-induced state or reaction is provoked by a drug.
Are ALT and AST liver enzymes?
ALT is an enzyme found in the liver that helps convert proteins into energy for the liver cells. When the liver is damaged, ALT is released into the bloodstream and levels increase. Aspartate transaminase (AST). AST is an enzyme that helps metabolize amino acids.
What is the meaning of drug-induced?
drug-induced in the Pharmaceutical Industry A drug-induced state or reaction is provoked by a drug. Narcotic overdoses cause a number of drug-induced deaths. Psychosis brought on by drug use is called drug-induced psychosis. A drug-induced state or reaction is provoked by a drug.
Is drug-induced hepatitis infectious?
Most noninfectious causes of hepatitis are not contagious. Hepatitis caused by alcohol poisoning, medications, or toxins or poisons are not transmitted from person to person.
What is the meaning of drug induced?
What happens in drug induced liver injury?
Patients with drug-induced fatty liver may have only a few symptoms, or none. They typically have mild to moderate elevations in blood levels of ALT and AST, and also may develop enlarged livers. In severe cases, drug-induced fatty liver can lead to cirrhosis and liver failure.
What is the treatment for drug-induced hepatitis?
There is no specific treatment for drug-induced hepatitis other than discontinuing the medication that is causing the problem. People with acute hepatitis should avoid physical exertion, alcohol, paracetamol and any other hepatotoxic substances.
What drugs can cause hepatitis C?
Injection drug abuse is the main risk factor associated with hepatitis C transmission. If you use syringes to inject drugs, such as LSD, cocaine or heroine into your body, it only takes one incident of sharing a syringe with an infected person to contract the virus.
What is hepatitis A, causes, symptoms and treatment?
Symptoms. Hepatitis A is an acute viral infection that affects the liver.
Is acute hepatitis life-threatening?
Acute hepatitis is seldom life-threatening. Most people recovery completing from acute hepatitis within a few weeks to months. Chronic hepatitis can cause progressive damage to the liver, including scarring of the liver leading to cirrhosis, liver failure, and liver cancer.
What does drug induced mean?
Abnormalities, Drug-Induced. Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances.
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