How do you detect JWH-018?
How do you detect JWH-018?
The first published method attempted to detect JWH-018 in the serum of a living human by liquid chromatography with tandem mass spectrometry (17). The extraction method was a liquid–liquid extraction with a hexane–ethyl acetate mixture and the overall run time for one specimen 6.5 min.
Where is JWH 018 found?
JWH 018 (Item No. 10900) is an analytical reference material categorized as a synthetic cannabinoid. It has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States.
Where is THCP found?
THCP was discovered by accident The study was conducted by a team of Italian researchers. They used advanced mass-spectrometry and liquid chromatography technology on a natural (not synthetic) cannabis sample (FM2) provided by the Military Chemical Institute in Florence, Italy.
What does JWH-019 stand for in medicine?
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. It is the N-hexyl homolog of the more common synthetic cannabinoid compound JWH-018.
Which is the legal analog of JWH-018?
Nevertheless, already a few months later, it was demonstrated that JWH-018 had been replaced in Spice products by one of its “legal” structural analogs, JWH-073 ( Lindigkeit et al., 2009 ).
Which is a homolog of the cannabinoid JWH-019?
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is the N -hexyl homolog of the more common synthetic cannabinoid compound JWH-018. Unlike the butyl homolog JWH-073, which is several times weaker than JWH-018,…
How is JWH-018 and AM-2201 metabolized?
JWH-018 and AM-2201 (its fluorinated analogue) are metabolized in the liver by CYP2C9 and 1A2. Thus, there is the potential to cause AE when given concurrently with medications such as valproic acid, warfarin, phenytoin, and ciprofloxacin.
