How do you get familial adenomatous polyposis?

How do you get familial adenomatous polyposis?

Familial adenomatous polyposis (FAP) is a rare, inherited condition caused by a defect in the adenomatous polyposis coli (APC) gene. Most people inherit the gene from a parent. But for 25 to 30 percent of people, the genetic mutation occurs spontaneously.

How do you know if you have familial adenomatous polyposis?

Familial Adenomatous Polyposis Diagnosis. Genetic testing is available for FAP as well as other hereditary colorectal conditions. A simple blood test can determine if you have the gene mutation that causes the disease in about 80 percent of families with FAP.

What is life expectancy with FAP?

Patients with untreated FAP have a median life expectancy of 42 years. Life expectancy is extended greatly in those treated with colectomy. Upper gastrointestinal cancers and desmoid tumors are the most common causes of death in patients who have undergone colectomy.

Is FAP or Lynch more common?

Lynch syndrome and familial adenomatous polyposis (FAP) are the most common and best known of the dominantly inherited colorectal cancer syndromes. Both arise from germline mutations that result in destabilization and deregulation of cell growth.

What is the treatment for familial polyposis coli?

Surgery is the standard treatment to prevent colorectal cancer in FAP. The timing and type of colon surgery depend on the number and size of the polyps in the large bowel. If the patient does not have a large number of colon polyps, surgery may not be recommended until later in his or her life.

How common is familial polyposis?

The reported incidence of familial adenomatous polyposis varies from 1 in 7,000 to 1 in 22,000 individuals.

How often should someone with Lynch syndrome have a colonoscopy?

Guidelines recommend colonoscopy every 1 – 2 years, starting at age 20 – 25 years, or 10 years younger than the age of first diagnosis in the family (whichever is first), and yearly after the age of 40 years 4 22 23 24 25 26.