Can meropenem cause neutropenia?
Can meropenem cause neutropenia?
Postmarketing surveillance has associated meropenem with the development of hematologic abnormalities, including agranulocytosis, neutropenia, and leukopenia, but the exact incidence in children is unknown.
What are the adverse effects in administering meropenem among infants?
Possible adverse effects
- Leukopenia, neutropenia, eosinophillia, thrombocytopenia and anaemia.
- Inflammation at injection site.
- Vomiting, diarrhoea, and constipation (1%).
- Rash (2%).
- Nephrotoxicity, hepatotoxicity.
Which antibiotics cause neutropenia?
The drugs most commonly associated with neutropenia are antibiotics (particularly beta-lactam and trimethoprim-sulfamethoxasole) as well as antithyroid drugs, antiplatelet agents, nonsteroidal anti-inflammatory agents, and noramidopyrin (3).
How long does drug induced neutropenia last?
Confirmation of drug-induced neutropenia is made by repeating the CBC and differential after withdrawal of the offending drug. The neutropenia usually resolves within 3 weeks.
Can antibiotics affect neutropenia?
Neutropenia is an uncommon but potentially serious complication of drug therapy. Many drugs, especially antibiotics, can produce this untoward effect. Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.
Can bactrim cause neutropenia?
Antibiotics such as Bactrim have a high incidence of neutropenia and are many times an unsuspecting culprits. Awareness of the increased risk of neutropenia associated with Bactrim use is important during clozapine therapy.
Is meropenem safe for baby?
Meropenem is currently approved by the Food and Drug Administration (FDA) for use in children ≥3 months of age with bacterial meningitis and/or complicated intra-abdominal infections; however, there is substantial off-label use of meropenem in infants <3.
Do antibiotics affect neutrophils?
Beta-lactam antibiotics have shown an effect on decreasing total neutrophil concentration in the plasma leading to decreased WBC count and neutropenia. This is thought to be caused by a combination of decreased granulopoiesis and induction of antibodies against the formation of haptens on neutrophils.
Is neutropenia reversible?
Transient neutropenia, in most circumstances, is reversible with removal of the offending agent. Neutropenia is defined as an absolute neutrophil count (ANC) < 1,500/μL.
How fast do neutrophils recover?
Neutrophil recovery will usually occur in three to four weeks following treatment. Exceptions to this include agents such as mitomycin, carmustine, and lomustine, which have a delayed nadir of about four to six weeks following administration of each cycle.
Do antibiotics affect WBC count?
Drugs that may decrease WBC counts include antibiotics, anticonvulsants, antihistamine, antithyroid drugs, arsenicals, barbiturates, chemotherapeutic agents, diuretics and sulfonamides.
What are the long term side effects of meropenem?
In clinical trials (n=2904), this drug was discontinued in 1.2% of patients due to side effects; 5 deaths were possibly drug-related. In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often.
Is it safe to give meropenem to children?
In conclusion, the present results showed that meropenem is a safe and tolerable antibiotic in children. The efficacy as an empirical monotherapy in paediatric cancer patients with febrile neutropenia was satisfactory, with a failure rate of 23.3% on day 5 of treatment.
What’s the half life of meropenem in newborns?
The initial half-life in term neonates is 2 hours and in the preterm neonates is 3 hours, but the half-life falls significantly, irrespective of gestation, within 10-14 days of life of birth. Meropenem has many of the same properties, and most of the same adverse effects, as imipenem, but it seems to cause less nausea.
What kind of infections can meropenem be used for?
The use of meropenem is the treatment of pneumococcal meningitis and other serious infections caused by susceptible gram-negative organisms resistant to other antibiotics, especially extended-spectrum β-lactamase producing Klebsiella pneumoniae.
https://www.youtube.com/watch?v=pH8Jc_a4YRU
