Is carboplatin less toxic than cisplatin?
Is carboplatin less toxic than cisplatin?
Carboplatin appears to be significantly less toxic than cisplatin. Whilst thrombocytopenia with carboplatin is dose limiting, in this study in patients with adequate renal function and bone marrow reserve myelosuppression was not severe and data suggests that there is scope for in- creasing the dose.
Which is better cisplatin or carboplatin?
Conclusions: For some tumors, cisplatin appears to be superior to carboplatin in terms of therapeutic effectiveness (germ cell tumors, bladder cancer, head and neck cancer), while for others, effectiveness is comparable (lung cancer, ovarian cancer).
How is carboplatin different from cisplatin?
Cisplatin and carboplatin have different toxicity profiles; cisplatin is associated with a higher rate of nausea, vomiting, nephrotoxicity, ototoxicity, while carboplatin has a higher risk of myelosupresssion and neurotoxicity6.
What is the benefit of carboplatin over cisplatin?
Meta-analyses of palliative chemotherapy indicate consistent survival advantages with cisplatin-based therapy over carboplatin; however, the relative advantage is small. Cisplatin carries a higher toxicity profile, including nausea, vomiting, neuropathy, renal insufficiency, and alopecia in comparison to carboplatin.
Why is carboplatin more stable than cisplatin?
The greater chemi- cal stability of carboplatin in comparison with cisplatin accounts for its lower reactivity with nucleophilic sites of DNA, and may therefore be related to the higher doses necessary to obtain antitumour effects similar to that of cisplatin [21].
Is cisplatin toxic?
Cisplatin treatment has been linked to various toxic side effects including nausea, nephrotoxicity, Cardiotoxicity, hepatotoxicity and neurotoxicity. Many toxic events have been reported in various studies that include arrhythmias, congestive heart failure, electro-cardiographicchanges as well as myocarditis.
What is cisplatin and carboplatin?
Cisplatin and carboplatin, represent some of the most active cytotoxic agents and are the backbone of most chemotherapeutic regimens. • Despite their relative similarities in mechanisms of action, there are significant differences in efficacy and toxicity in various malignancies.
What are the long term side effects of carboplatin?
Sensory loss, numbness and tingling, and difficulty in walking may last for at least as long as therapy is continued. These side effects may become progressively more severe with continued treatment, and your doctor may decide to decrease your dose.
Is carboplatin a platinum based chemo?
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events).
What is carboplatin cisplatin?
The platinum analogues, cisplatin and carboplatin, are among the most widely used chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity in numerous malignancies including gynaecological cancers, germ cell tumours, head and neck cancer, thoracic cancers and bladder cancer.
Is carboplatin a platinum-based chemo?
Does cisplatin cause neurotoxicity?
The range of cisplatin-induced neurotoxicity includes peripheral neuropathy, ototoxicity (hearing impairment and tinnitus), vestibulopathy, and encephalopathy; the most common are peripheral neuropathy and ototoxicity.
Which is better for lung cancer cisplatin or carboplatin?
Cisplatin vs. carboplatin-based chemoradiotherapy in patients >65 years of age with stage III non-small cell lung cancer Carboplatin-based CRT is associated with similar long-term survival but lower rates of toxicity. These findings suggest carboplatin may be the most appropriate chemotherapeutic agent for elderly stage III patients.
Is the platinum molecule the same as cisplatin?
The platinum (II) molecules exist in a planar structure in with the two amine groups and the two reactive “leaving” chloride (cisplatin) and cyclobutane-decarboxylate (carboplatin) groups existing in the same configuration ( Fig. 1) ( Reed, 1998 ).
Which is a passive transporter for cisplatin and carboplatin?
Passive transporters have also been implicated in the cellular influx of cisplatin and carboplatin. The solute carrier (SLC) gene encodes a large family of passive transporters predominated by ion-coupled transporters and exchangers.
Which is better cisplatin or taxotere for NSCLC?
Having one doublet do significantly better than any other is pretty rare, so that’s why some people would perhaps consider the cisplatin/taxotere doublet to be among the most active combinations for NSCLC, albeit by a small margin.
