What is solution phase synthesis?
What is solution phase synthesis?
Solution phase synthesis was the first developed and the only method for peptide synthesis until the solid phase peptide synthesis (SPPS) introduced by Merrifield revolutionized the way peptides and their analogues are prepared nowadays.
What is meant by solid phase synthesis in combinatorial chemistry?
In chemistry, solid-phase synthesis is a method in which molecules are covalently bound on a solid support material and synthesised step-by-step in a single reaction vessel utilising selective protecting group chemistry. Benefits compared with normal synthesis in a liquid state include: High efficiency and throughput.
Which method is used in combinatorial synthesis?
From the stand point of the synthetic chemist, Combinatorial Synthesis involves the use of processes (solid phase synthesis) and strategies (hundreds or thousands of simultaneous reactions) which allow the preparation, in a short time, of big, organized collections of organic compounds, the so called molecular …
What is solution phase peptide synthesis?
Abstract. Solution phase synthesis was the first developed and the only method for peptide synthesis until the solid phase peptide synthesis (SPPS) introduced by Merrifield revolutionized the way peptides and their analogues are prepared nowadays.
What is combinatorial chemistry describe the solid phase and solution phase synthesis?
A common combinatorial technique uses organic synthesis on solid support. Linker groups are attached to resin beads in the solid phase and the reactants are passed over in solution to make the intermediates and a final detachment-from-resin reaction is run to get the desired product out of the column.
What is a solution phase?
The use of solution phase techniques has been explored as an alternative to solid-phase chemistry approaches for the preparation of arrays of compounds in the drug discovery process. Solution-phase work is free from some of the constraints of solid-phase approaches but has disadvantages with respect to purification.
What is solid phase Peptide Synthesis explain with example?
Solid-phase peptide synthesis (SPPS) involves the successive addition of protected amino acid derivatives to a growing peptide chain immobilized on a solid phase, including deprotection and washing steps to remove unreacted groups and also side products.
How can combinatorial chemistry is different than conventional synthesis?
The basic principle of combinatorial chemistry is to prepare a large number of different compounds at the same time Instead of synthesizing compounds in a conventional one at a time manner and then to identify the most promising compound for further development by high throughput screening (Process that allows rapid …
What is the main principle of combinatorial chemistry?
Combinatorial chemistry is based on the principle of making a large number of chemical compounds rapidly on a small scale in small reaction cells. This practice is widely adopted by the pharmaceutical sector for use during the drug designing and screening stages.
What do you mean by combinatorial chemistry?
Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. Combinatorial chemistry can be used for the synthesis of small molecules and for peptides.
What is a solution in chemistry?
solution, in chemistry, a homogenous mixture of two or more substances in relative amounts that can be varied continuously up to what is called the limit of solubility. The term solution is commonly applied to the liquid state of matter, but solutions of gases and solids are possible.
