Where can I get tetrodotoxin?

Where can I get tetrodotoxin?

DESCRIPTION: Tetrodotoxin is an extremely potent poison (toxin) found mainly in the liver and sex organs (gonads) of some fish, such as puffer fish, globefish, and toadfish (order Tetraodontiformes) and in some amphibian, octopus, and shellfish species.

How much does tetrodotoxin cost?

Technical Guides

Can you make tetrodotoxin?

Scientists have now introduced a new route for the total synthesis (complete production of a natural product from current materials) of tetrodotoxin. In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin.

Can you buy TTX?

Product Description Tetrodotoxin with citrate can be dissolved in water to obtain TTX in pH 4.8 citrate buffer. Chemical Structure: Note: This product is not available for sale outside of the U.S.

What can tetrodotoxin be used for?

Because TTX blocks voltage-gated sodium channel and causes paralysis, it can also be applied as a potential pain relief and some researchers are trying to make use of the analgesic activity of TTX to treat various types of pains such as severe cancer pain [29,30,31], or to help in reducing cue-induced increases in …

Does tetrodotoxin stop the heart?

The transient or permanent reduction of the heart rate is most likely the result of a complex systemic reaction to TTX intoxication.

What is the usefulness of tetrodotoxin?

Is tetrodotoxin reversible?

Tetrodotoxin is a reversible, potent, selective and high affinity inhibitor of voltage gated sodium channels Nav 1.6, 1.1, 1.3, 1.4, 1.2 and 1.7 (IC50 values are 2.3 nM, 4.1 nM, 5.3 nM, 7.6 nM, 14 nM and 36 nM, respectively). Binding is reversible and high affinity (Kd = 1-10 nM).

How poisonous is tetrodotoxin?

Toxicity of Tetrodotoxin In human, the lethal dose of tetrodotoxin is around 1 to 2 mg and the minimum dose necessary to cause symptoms has been estimated to be 0.2 mg. The onset of symptoms of tetrodotoxin intoxication usually occurs from 10 to 45 minutes after ingestion, but may be delayed by three hours or more.

What does tetrodotoxin mean?

Definition of tetrodotoxin : a neurotoxin C11H17N3O8 found especially in puffer fish that blocks nerve conduction by suppressing permeability of the nerve fiber to sodium ions.

What is tetrodotoxin citrate?

Tetrodotoxin citrate, the water-soluble citrate salt of tetrodotoxin, is a reversible, potent, selective and high affinity inhibitor of voltage gated sodium channels Nav 1.6, 1.1, 1.3, 1.4, 1.2 and 1.7 (IC50 values are 2.3 nM, 4.1 nM, 5.3 nM, 7.6 nM, 14 nM and 36 nM, respectively).

Is tetrodotoxin flammable?

Flammability (solid, gaseous): Product is not flammable.

Is it safe to take tetrodotoxin in humans?

Tetrodotoxin is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and muscle action potentials. Products are for laboratory research use only. Not for human use. We do not sell to patients. Saurabh Pandey, .et al.

What kind of action does tetrodotoxin have on the body?

Tetrodotoxin is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and muscle action potentials. * The above data is based on the productmolecular weight 319.27.

What is the cat number for tetrodotoxin citrate?

Tetrodotoxin citrate (Cat. No. 1069) also available. The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Where does tetrodotoxin come from in a pufferfish?

Rather, tetrodotoxin is likely produced by the bacteria Vibrio alginolyticusm, which are found in the intestines of pufferfish and others, and make up the poisonous part of their microbiome. If you’re not familiar with the word, microbiome is just the collection of microorganisms that share our bodily space. It’s science’s newest hot topic.