What does Shc protein mean?
What does Shc protein mean?
SHC1 (SHC (Src homology 2 domain containing) transforming protein 1)
| Nomenclature | |
|---|---|
| Atlas | SHC1ID42287ch1q21 |
| Entrez_Gene (NCBI) | SHC1 SHC adaptor protein 1 |
| Aliases | SHC; SHCA |
| GeneCards (Weizmann) | SHC1 |
Is Shc an adaptor protein?
Shc proteins are the only adaptor proteins that possess both a PTB (phosphor-tyrosine binding) domain as well as a SH2 (Src homology 2) domain [1].
What is the Shc domain?
The SH2 domain of Shc, which is located at its very C-terminus, was initially characterized as a domain responsible for its recruitment to the activated epidermal growth factor (EGF) receptor and was implicated in EGF-dependent tyrosine phosphorylation of Shc (Pelicci et al., 1992).
Does RTKs have SH2 domains?
What Do RTKs Look Like? Once cross-phosphorylated, the cytoplasmic tails of RTKs serve as docking platforms for various intracellular proteins involved in signal transduction. These proteins have a particular domain — called SH2 — that binds to phosphorylated tyrosines in the cytoplasmic RTK receptor tails.
What does SHC mean?
SHC
| Acronym | Definition |
|---|---|
| SHC | Storage Host Component |
| SHC | Spontaneous Human Combustion |
| SHC | Squalene-Hopene Cyclase (enzyme) |
| SHC | Solar Heating and Cooling |
What does SHC mean in medical terms?
The Full Form of SHC is Serious Health Condition.
What is the meaning of SHC?
SHC
| Acronym | Definition |
|---|---|
| SHC | Sexual Health Centre (various locations) |
| SHC | Speech and Hearing Center (various locations) |
| SHC | Springfield Hospital Center (Maryland) |
| SHC | System Health Check |
What is SHC insulin?
Shc is composed of 46-, 52-, 66-kDa isoforms which arise from alternative splicing of the primary Shc transcript. Upon insulin stimulation, the activated insulin receptor interacts with Shc. The NPXY motif around 960-Tyr residue of the insulin receptor binds to the N-terminal PTB domain of Shc.
What is JAK1 and JAK2?
JAK1 and JAK2 are involved in type II interferon (interferon-gamma) signalling, whereas JAK1 and TYK2 are involved in type I interferon signalling. Mice that do not express TYK2 have defective natural killer cell function.
What is the full form of Sch?
SCH. Semester Credit Hour. Academic & Science » Universities.
What is the full form of Shcs?
SHCS Stands For : Senior Chief Ship Serviceman.
How is SHC1 a dynamic scaffold protein?
SHC1 is not a static scaffold protein, a protein that does not move or change over time, it is dynamic as the conformation changes and modifies the EGFR signaling output over time. SHC proteins are differentially regulated by the Multiple Copies in T-cell malignancy (MCT-1).
What does SHC1 Shc adaptor protein 1 do?
SHC1 SHC adaptor protein 1 [ (human)] Summary. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species.
Where is the SHC1 gene located on the chromosome?
The gene SHC1 is located on chromosome 1 and encodes 3 main protein isoforms: p66SHC, p52SHC and p46SHC. These proteins differ in activity and subcellular locations, p66 is the longest and while the p52 and p46 link activated receptor tyrosine kinase to the RAS pathway.
How is SHC1 used as a prognostic marker?
Clinical significance. The signaling activation of SHC is implicated in tumorigenic in cancer cells there is a potential to use SHC as a prognostic marker when targeting cancer treatment. SHC1 interacts with SgK269 which is a member of the Src kinase signaling network that characterized basal breast cancer cells.
