How long do G-CSF injections take to work?
How long do G-CSF injections take to work?
This usually takes 5 to 7 days, although it can be longer. Long-acting G-CSF is given as a single injection the day after chemotherapy has completed. If you are having G-CSF before a stem cell transplant, you usually have your first injection 4 to 6 days before your stem cells are going to be collected.
What are G-CSF injections for?
Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy.
When should you not give G-CSF?
GCSF should not be administered within 24 hours of cytotoxic chemotherapy- therefore start at least 24 hours after the completion of chemotherapy and stop at least 24 hours before next chemotherapy due.
Why does G-CSF cause bone pain?
Background: The bone pain frequently emerges as one of the side effects of G-CSF administration. Rising pressure within bone marrow by increased granulocytes, edema within bone marrow by histamine release, and increased level of bradykinin are thought to be the mechanisms underlying it.
How much does G-CSF cost?
Injectable Solution
| Quantity | Per unit | Price |
|---|---|---|
| 0.5 milliliters | $715.76 | $357.88 |
| 5 (10 x 0.5 milliliters) | $698.68 | $3,493.38 |
Why does Claritin help with bone pain?
Claritin is an antihistamine that blocks histamine, so decreases the amount of inflammation and swelling in the bone marrow and therefore reduces the pain.
Why does Zyrtec help with bone pain?
G-CSF causes a release of histamine that may be a cause of chronic bone pain. Loratadine targets histamine, and so may be effective in reducing bone pain.
Does G-CSF increase platelet count?
Primarily, G-CSF stimulates the bone marrow to produce granulocytes and stem cells. A decreased platelet count was occasionally observed after G-CSF injection. A previous study indicated that G-CSF also increases platelet turnover and loss.
What’s the best medicine for bone pain?
To ease your bone pain, your healthcare provider may recommend Tylenol (acetaminophen) or a non-steroidal anti-inflammatory drug (NSAID) like Advil (ibuprofen).
