Are there any alternatives to phthalates?

DEHT/DOTP and DINCH Both can replace phthalates, often DEHP and DINP, in almost all plasticiser applications. Terephthalates, the group to which DEHT (sometimes called DOTP) belongs, represent 42% of the market for alternative plasticisers.

Is DINP safe?

Diisononyl phthalate (DINP) can lead to growth of tumors in the liver, spleen and kidneys of animals and can affect how unborn babies develop. It may also cause cancer in humans.

What are names for phthalates?

What are phthalates and how are they used?

DBP (dibutyl phthalate)
DNOP (di-n-octyl phthalate)
DiNP (diisononyl phthalate)
DEP (diethyl phthalate)
BBzP (benzyl butyl phthalate)
DEHP (di 2-ethylhexl phthalate)
DiDP (diisodecyl phthalate)
DnHP (di-n-hexyl phthalate)

What is an ortho phthalate?

Ortho-phthalates, commonly referred to as phthalates (pronounced THAL-eights), are a group of chemicals that are used to make plastics, primarily polyvinyl chloride (PVC or vinyl), flexible. The chemicals also serve other purposes, including as solvents in fragrances for personal care and cleaning products.

Is PVC without phthalates safe?

While the use of this new form of PVC reduces potential toxicity as it eliminates the greatest hazard from the material, the use of PVC remains controversial as it continues to present certain dangers – PVC in its phthalate-free form may still contain dioxin (a known carcinogen), VOCs (see link below), as well as lead …

What has Diisononyl phthalate?

DINP is used in various types of plastic consumer products, including: Some polyvinyl chloride (PVC, vinyl) flooring, materials used in automobile interiors, wire and cable insulation, gloves, tubing, garden hoses, and shoes.

Do Ziploc bags have phthalates?

“Glad food containers, wraps, and storage bags and other food contact products are not made of phthalates or polycarbonate. “Our Saran™ and Ziploc® products do not contain harmful plasticizers, including those associated with endocrine disruption such as adipates (DEHA) or phthalates (DEHP).”

How does benzyl butyl phthalate affect breast cancer cells?

Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) [1] [2] [3] . Benzyl butyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity [1].

What can be used as an alternative to phthalates?

One class of alternative plasticizers to phthalates is bio-based plasticizers. Bio-based alternatives can be made from plant materials such as corn, soy, rice, wheat, and linseed, which makes them much less threatening to animal life.

Are there any restrictions on the use of phthalates?

A number of regulatory authorities have begun taking steps to more closely regulate certain phthalates. For example: Congress has prohibited the use of DBP, DEHP, and another phthalate—butyl benzyl phthalate (BBP)—in children’s toys at concentrations higher than 0.1 percent (Consumer Product Safety Improvement Act 2008).

Can a phthalate be used in a biologic product?

Of the phthalates for which significant concern has been expressed because of their reproductive and developmental toxicity, only DBP and DEHP have been used in CDER-regulated drug or biologic products. The recommendations in this guidance apply only to DBP and DEHP.

Are there any alternatives to phthalates?