What is the pathogenesis of bacterial meningitis?

Most cases of bacterial meningitis develop as a result of haematogenous spread, but it is unclear how circulating bacteria cross the blood–brain barrier, and how bacterial entry into the central nervous system results in inflammation and in complications such as pleocytosis, blood–brain barrier disruption and neuronal …

Which manifestation S is are most significant in the diagnosis of bacterial meningitis?

For the diagnosis of Meningococcal Meningitis, the most significant group of diagnostic criteria identified included haemorrhagic rash (OR 22.36), absence of seizures (OR 2.51), headache (OR 1.83) and negative gram stain result (OR 1.55) with a Positive Predictive Value (PPV) of 96.4% (95%CI 87.7–99.6).

What alteration in physiology occurs with bacterial meningitis What signs and symptoms occur with bacterial meningitis?

Up to 95% of patients with bacterial meningitis have at least two of the four following symptoms: fever, headache, stiff neck, or altered mental status. Other symptoms can include nausea, vomiting, photalgia (photophobia), sleepiness, confusion, irritability, delirium, and coma.

How do you write a pathophysiology?

The page name should be “(Disease name) pathophysiology”, with only the first letter of the title capitalized. Goal: to explain the biological mechanisms underlying the disease state.

What are the causes of bacterial meningitis?

Bacterial meningitis is caused by several different types of bacteria, including:

Streptococcus pneumoniae, also called pneumococcus.
Neisseria meningitidis, also called meningococcus.
Haemophilus influenzae, also called Hib.
Listeria monocytogenes.
group B strep.
E. coli.

What are the causes of pathophysiology meningitis?

Pathophysiology Meningitis is a disease process where the protective layers that cover the brain and spinal cord become inflamed. Meningitis can be infectious or it can be caused by injury, cancer, and other noninfectious causes. Infectious meningitis can be caused by a bacterial, viral, or fungal infection.

Which is a more dramatic change in epidemiology than bacterial meningitis?

This person is not on ResearchGate, or hasn’t claimed this research yet. No bacterial disease has undergone a more dramatic change in epidemiology during the past decade than acute bacterial meningitis.

Which is a hallmark of bacterial meningitis ( CSF )?

The pathogens take advantage of the specific features of the immune system in the CNS, replicate and induce inflammation [Simberkoff et al.1980]. A hallmark of bacterial meningitis is the recruitment of highly activated leukocytes into the CSF.

What is the white blood cell count in bacterial meningitis?

The CSF in bacterial meningitis is characterized by a strongly elevated white blood cell count (<500 cells/μl) with predominant neutrophils and a strongly elevated protein (< 1 g/l), indicating severe blood—CSF barrier disruption.

What is the pathogenesis of bacterial meningitis?