What is a translocation in genetics?
What is a translocation in genetics? Listen to pronunciation. (TRANZ-loh-KAY-shun) A genetic change in which a piece of one chromosome breaks off and attaches to another chromosome. Sometimes pieces from two different chromosomes will trade places with each other. What is the translocation of acute promyelocytic leukemia? Acute promyelocytic leukemia is characterized by a specific t(15;17) chromosomal translocation and a particular sensitivity to retinoic acid. The translocation fuses the PML gene to the retinoic acid receptor alpha (RAR alpha) gene resulting in the production of a PML-RAR alpha fusion protein. How is Apml different from AML? Acute promyelocytic leukaemia (APML)...