What triggers macropinocytosis?
What triggers macropinocytosis? Macropinocytosis is usually initiated by external stimulation. The stimulus is commonly in the form of growth factors that trigger activation of receptor tyrosine kinases (RTKs). These, in turn, activate a signalling cascade that induces changes in the dynamics of actin filaments and trigger plasma membrane ruffling. What cells use macropinocytosis? Macropinosomes can subsequently undergo homotypic fusion and fission and also traffic to other organelles in the endolysosomal system [10]. Much of the early work on macropinocytosis was focused on the immune cells, dendritic cells and macrophages. Why does excessive macropinocytosis lead to cell death? Macropinocytosis not only...