What is PLA and PLGA?
What is PLA and PLGA? Polylactide (PLA) and Poly (lactic-co-glycolic acid) (PLGA) are biodegradable, aliphatic polyesters prepared by the condensation of biological monomers as lactic acid (i.e. PLA) or lactic acid and glycolic acid (i.e. PLGA). Is PLGA safe? Background. Poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) are among the well-documented FDA-approved polymers used for the preparation of safe and effective vaccine, drug and gene delivery systems using well-described reproducible methods of fabrication. Why does PLGA degrade faster than PLA? In water, PLGA biodegrades by hydrolysis of its ester linkages (Figure 2). Presence of methyl side groups in PLA makes...