What Causes copy number alterations?
What Causes copy number alterations? A likely source of copy number variation is incorrect repair of DNA damage. Genomic duplication and triplication of the gene appear to be a rare cause of Parkinson's disease, although more common than point mutations. Is copy number variation bad? Evidence is accumulating that certain CNVs have impact on susceptibility to human diseases such as HIV infection and autoimmune diseases, as well as on adaptability to environmental conditions or nutrition. Can fish detect copy number variation? As Kim Caple, vice president of marketing, microarrays, at Thermo Fisher Scientific, points out: “FISH is visual—subjective.” Although it...